Results 191 to 200 of about 22,032 (260)

Biofunctionalized Vascular Access Graft Improves Patency and Endothelialization in a Porcine Arteriovenous Model. [PDF]

J Funct Biomater
Battistella A, Linger M, Overton M, Uriyanghai U, Wai C, Xi G, Roy-Chaudhury P, Tan W.   +7 more
europepmc   +1 more source

Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery

Angewandte Chemie, EarlyView.
We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne, Sona Krajcovicova, Graeme Davies, Hannah Bolt, Jefferson Revell, David R. Spring   +5 more
wiley   +2 more sources

HelixSide: A Comprehensive Method for Local and Global Orientational Analysis of Proteins. [PDF]

J Chem Inf Model
Pirnes S, Hägg V, Girych M, Vattulainen I, Enkavi G.   +4 more
europepmc   +1 more source

Nitro Reduction‐Based RNA Control and Ultrafast Release

Angewandte Chemie, EarlyView.
A chemical RNA caging–uncaging strategy based on nitro reduction is described. Nitroaryl groups introduced via acylation temporarily block the functions of diverse RNAs in vitro and in living cells. Treatment with a diboronic acid–bipyridine mixture rapidly reduces the nitro groups, releasing RNAs and restoring their activity.
Yiran Zhao, Senfeng Zhang, Junsong Guo, Tuan‐Khoa Kha, Song Chen, Chunyi Hu, Ru‐Yi Zhu   +6 more
wiley   +2 more sources

Bifurcation analysis and analytical traveling wave solutions of a sasa-satsuma equation involving beta, M-truncated and conformable derivatives using the EGREM method. [PDF]

Sci Rep
Munir F, Saad KM, Abbas M, Birhanu A, Hamanah WM, Nazir T.   +5 more
europepmc   +1 more source

Exploring the new classes of optical soliton solutions with diverse structure for the (2+1)-dimensional paraxial equation in fiber optics via two analytical methods. [PDF]

Sci Rep
Ibrahim IS, Sabi'u J, Iqbal M, Sulaiman S, Alghabban WG, Gouadria S, Nazar NM.   +6 more
europepmc   +1 more source

Investigation on dynamical perspective of soliton solutions to the nonlinear integrable Akbota equation through a generalized analytical technique. [PDF]

Sci Rep
Iqbal M, Faridi WA, Alrashdi HD, Algethamie R, Aljohani A, El-Meligy M, Nazar NM, Alnowibet KA.   +7 more
europepmc   +1 more source

Integrating sequence-based GWAS and comparative genomic analysis reveals conservation and species-specificity of putative functional variants influencing tail length and tail abnormalities in pigs and sheep. [PDF]

PLoS One
Zhang X, Mainzer J, Giambra I, Yin T, Engel P, Hümmelchen H, Wagner H, Wehrend A, Egerer C, Gerhards K, Reiner G, König S.   +11 more
europepmc   +1 more source

Soliton dynamics and stability analysis of a double-chain DNA model with various chaos detection tools. [PDF]

Sci Rep
Ullah MS, Akter R.
europepmc   +1 more source

Propagation of optical solitons and dispersive solitary wave structure in complex media to the nonlinear integrable system via computational technique. [PDF]

Sci Rep
Iqbal M, Faridi WA, Algethamie R, Aljohani A, El-Meligy M, Mohammad N, Alnowibet KA.   +6 more
europepmc   +1 more source