Results 51 to 60 of about 302 (171)

Biochemical and structural characterization of a tail‐spike protein with depolymerase activity identified in a marine podovirus

Acta Crystallographica Section D, EarlyView.
The marine tail‐spike protein Dpo31 degrades the exopolysaccharide of its host and has structural features similar to those of other members of this protein class, despite similarity not being detected at the sequence level.Marine phages are, through the infection of their bacterial hosts, key regulators of microbiome and carbon fluxes in the ocean ...
Serena Sirigu, Thomas Roret, Pierre-Yves Mocaër, Robert Larocque, Diane Jouanneau, Pierre Legrand, Anne-Claire Baudoux, Mirjam Czjzek   +7 more
wiley   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, EarlyView.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

An Anisotropic Peridynamic Model for Simulating Crack Propagation in Isotropic and Anisotropic Rocks. [PDF]

Materials (Basel), 2023
Tian K, Zhu Z, Sheng Q, Tian N.
europepmc   +1 more source

Neutrophil Secretory Proteins Inhibit Calcium Oxalate Crystallisation and Crystal Growth, but Promote Crystal Aggregation

Immunology, EarlyView.
Calcium oxalate monohydrate (COM) crystals cause changes in the secretion of 29 proteins from neutrophil‐like cells, including those involved in neutrophil immune activation and intracellular metabolic adaptation. The neutrophil secreted proteins (secretome) also inhibit calcium oxalate crystallisation and crystal growth, but promote crystal ...
Chanettee Lertprapai, Paleerath Peerapen, Visith Thongboonkerd   +2 more
wiley   +1 more source

Characterisation of human hair follicle development

Journal of Anatomy, EarlyView.
Schematic of hair follicle development in human skin. Hair follicle primordia of similar sizes, but different densities, are laid out across the skin. The distinction between terminal and vellus hair sites is not obvious at early stages of hair follicle development.
Zoe R. Sudderick, James D. Glover, Cameron Batho‐Samblas, Barbara Bo‐Ju Shih, Denis J. Headon   +4 more
wiley   +1 more source

Confirming the impact origin of the São Miguel do Tapuio structure, northeastern Brazil

Meteoritics &Planetary Science, EarlyView.
Abstract The São Miguel do Tapuio structure (SMT) is a remarkable, nearcircular feature of about 21 km diameter, centered at 5°37.6′ S, 41°23.3′ W in Piauí state, northeastern Brazil. The structure is located within the sedimentary strata of the Paleozoic–Mesozoic Parnaíba Basin and predominantly comprises sandstones of the Devonian Pimenteiras and ...
Alvaro Penteado Crósta, Neivaldo Araújo de Castro, Marcos Alberto Rodrigues Vasconcelos, Airton Natanael Coelho Dias, Ludovic Ferrière, Wolf Uwe Reimold, Ana Maria Góes, Jackson Alves Martins, Liliana Sayuri Osako, Raimundo Mariano Gomes Castelo Branco   +9 more
wiley   +1 more source

Impact‐diagnostic criteria for use in confirming a meteorite impact origin of terrestrial geological structures: Recommendations by the Impact Cratering Committee of the Meteoritical Society

Meteoritics &Planetary Science, EarlyView.
Abstract The framework of the Impact Cratering Committee (ICC) of the Meteoritical Society was approved in 2020, with the first committee members appointed in 2023. The ICC has a mandate to (1) approve, maintain, and update a database of confirmed terrestrial meteorite impact structures, (2) define and regularly update the criteria used for ...
A. J. Cavosie, S. Alwmark, D. Baratoux, G. Consolmagno, L. Ferrière, S. Goderis, N. Hauser, T. Kenkmann, C. Koeberl, G. R. Osinski, A. E. Pickersgill, M. Schönbächler   +11 more
wiley   +1 more source

Natural Variation in GmSL20 Improves Seed Size and Quality in Soybean

Plant Biotechnology Journal, EarlyView.
ABSTRACT Seed size plays an important role in determining crop yield, yet the genetic mechanisms underlying the regulation of this agronomic trait remain incompletely understood in soybean. Here, we perform a genome‐wide association study mapping with seed length variations and identify a major quantitative trait locus (QTL) on chromosome 20, named ...
Yuechuan Luo, Zongbiao Duan, Juxu Li, Zhou Zhu, Tong Wu, Dan Li, Yangping Liu, Liangwei Xu, Hao Wen, Yanting Shen, Shulin Liu, Qingtian Li, Zhixi Tian   +12 more
wiley   +1 more source

A combination of modified Kuhnt–Szymanowski and Celsus–Hotz techniques for correction of entropion and overlong lower eyelids in dogs (40 eyes)

Veterinary Ophthalmology, Volume 28, Issue 2, Page 114-123, March 2025.
Abstract Purpose To describe a surgical approach to correct entropion and overlong lower eyelids in dogs by combining the Celsus–Hotz with the modified Kuhnt–Szymanowski technique. Methods Medical records of patients undergoing the described surgical procedure were reviewed.
Hanna Walter, Teresa Bilotta, Catarina Goncalves, Claudia Busse   +3 more
wiley   +1 more source