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Monoterpenes in Vascular Function: A Review of Bioactivity and Mechanisms of Action. [PDF]
Int J Mol SciGonçalves T +7 more
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Agonizing GABA<sub>B</sub>R suppresses GLP-1RA's chronotropic effect and reduces post-myocardial infarction arrhythmogenesis. [PDF]
Front PharmacolQi R +7 more
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Kir3 channel signalling complexes in cardiac arrhythmias
Drug Discovery Today: Disease Models, 2012G protein-modulated inwardly rectifying potassium channels (Kir3, GIRK) are crucial integrators of G protein-coupled receptor (GPCR) signalling and play key roles in the stabilization of resting membrane potential in excitable and non-excitable cells. Here we discuss their roles in the heart, with a specific focus on how they might be involved in two ...
Peter Zylbergold, Terence E. Hébert
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Melatonin receptors activate heteromeric G-protein coupled Kir3 channels
NeuroReport, 1996The effects of melatonin on circadian pacemaker activity in the central nervous system may be the result of melatonin receptor activation of G-protein coupled potassium channels which inhibit the action potential firing of neurons. Xenopus laevis and human1a melatonin receptors stimulated heteromeric G-protein activated inwardly rectifying potassium ...
Nelson, CS, Marino, JL, Allen, CN
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Intracellular trafficking and assembly of specific Kir3 channel/G protein complexes
Cellular Signalling, 2009We have previously demonstrated that Kir3.1 channels and Gbeta1gamma2 subunits initially interact in the endoplasmic reticulum (ER). To elucidate the role that anterograde protein trafficking pathways may play in the formation of these complexes, we used dominant negative (DN) mutants of the small G proteins Sar 1 and various compartment-specific Rabs ...
Robitaille, Melanie +3 more
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Kir3 channels undergo arrestin-dependant internalization following delta opioid receptor activation
Cellular and Molecular Life Sciences, 2015Kir3 channels control excitability in the nervous system and the heart. Their surface expression is strictly regulated, but mechanisms responsible for channel removal from the membrane remain incompletely understood. Using transfected cells, we show that Kir3.1/3.2 channels and delta opioid receptors (DORs) associate in a complex which persists during ...
Karim, Nagi +2 more
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Interaction of G Protein β Subunit with Inward Rectifier K+ Channel Kir3
Molecular Pharmacology, 2003G protein betagamma subunits bind and activate G protein-coupled inward rectifier K+ (GIRK) channels. This protein-protein interaction is crucial for slow hyperpolarizations of cardiac myocytes and neurons. The crystal structure of Gbeta shows a seven-bladed propeller with four beta strands in each blade.
Qi, Zhao +5 more
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A novel, radiolabel-free pulse chase strategy to study Kir3 channel ontogeny
Journal of Receptors and Signal Transduction, 2013Kir3 channels are essential regulators of cellular excitability, maintaining cells at resting membrane potentials. While much research has been dedicated to elucidating the mechanisms regulating Kir3 channel gating, little is known regarding the channel's early associations with signaling partners, its stability at the plasma membrane or mechanisms ...
Peter, Zylbergold +2 more
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DNA Origami Scaffolds as Templates for Functional Tetrameric Kir3 K+ Channels
Angewandte Chemie, 2018AbstractIn native systems, scaffolding proteins play important roles in assembling proteins into complexes to transduce signals. This concept is yet to be applied to the assembly of functional transmembrane protein complexes in artificial systems.
Tatsuki, Kurokawa +14 more
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