Results 171 to 179 of about 2,269 (179)

Interaction of Gαq and Kir3, G Protein-Coupled Inwardly Rectifying Potassium Channels

Molecular Pharmacology, 2007
Activation of substance P receptors, which are coupled to Galpha(q), inhibits the Kir3.1/3.2 channels, resulting in neuronal excitation. We have shown previously that this channel inactivation is not caused by reduction of the phosphatidylinositol 4,5-bisphosphate level in membrane.
Takeharu, Kawano, Peng, Zhao, Christina V, Floreani, Yasuko, Nakajima, Tohru, Kozasa, Shigehiro, Nakajima   +5 more
openaire   +2 more sources

Up‐regulation of atrial and neuronal Kir3 activity by cholesterol

The FASEB Journal, 2017
Cholesterol is one of the major lipid components of the plasma membrane in mammalian cells, and its excess is associated with multiple pathological conditions including cardiovascular and neurodegenerative disease. In recent years, cholesterol has been emerging as a major regulator of ion channel function.
Avia Rosenhouse‐Dantsker, Anna N Bukiya   +1 more
openaire   +1 more source

Co-expression of Human Kir3 Subunits Can Yield Channels with Different Functional Properties

Cellular Signalling, 1999
To date, no comprehensive study has been done on all combinations of the human homologues of the Kir3.0 channel family, and the human homologue of Kir3.3 has not yet been identified. To obtain support for the contention that most of the functional data on non-human Kir3.0 channels can be extrapolated to human channels, we have cloned the human ...
O, Schoots, J M, Wilson, N, Ethier, E, Bigras, T E, Hebert, H H, Van Tol   +5 more
openaire   +2 more sources

Chloroform is a potent activator of cardiac and neuronal Kir3 channels

Naunyn-Schmiedeberg's Archives of Pharmacology, 2019
Chloroform has been used over decades in anesthesia before it was replaced by other volatile anesthetics like halothane or sevoflurane. Some of the reasons were inadmissible side effects of chloroform like bradycardia or neural illness. In the present study, we identified members of the G protein-activated inwardly rectifying potassium channel family ...
Sina, Kollert, Frank, Döring, Ulrich, Gergs, Erhard, Wischmeyer   +3 more
openaire   +2 more sources

Unifying Mechanism of Controlling Kir3 Channel Activity by G Proteins and Phosphoinositides

2015
The question that started with the pioneering work of Otto Loewi in the 1920s, to identify how stimulation of the vagus nerve decreased heart rate, is approaching its 100th year anniversary. In the meantime, we have learned that the neurotransmitter acetylcholine acting through muscarinic M2 receptors activates cardiac potassium (Kir3) channels via the
Diomedes E, Logothetis, Rahul, Mahajan, Scott K, Adney, Junghoon, Ha, Takeharu, Kawano, Xuan-Yu, Meng, Meng, Cui   +6 more
openaire   +2 more sources

Patch Clamp Analysis of Opioid-Induced Kir3 Currents in Mouse Peripheral Sensory Neurons Following Nerve Injury

2020
Patch clamp is an electrophysiological technique that allows to analyze the activity of ion channels in neurons. In this chapter, we provide a detailed description of patch clamp protocol to measure the effect of a μ-opioid receptor agonist on the activity of G protein-coupled inwardly rectifying potassium (GIRK or Kir3) channels.
Viola, Seitz, Philip, Stötzner, Dominika, Labuz, Halina, Machelska   +3 more
openaire   +2 more sources

Design and construction of conformational biosensors to monitor ion channel activation: A prototype FlAsH/BRET-approach to Kir3 channels

Methods, 2016
Ion channels play a vital role in numerous physiological functions and drugs that target them are actively pursued for development of novel therapeutic agents. Here we report a means for monitoring in real time the conformational changes undergone by channel proteins upon exposure to pharmacological stimuli.
Derek N, Robertson, Rory, Sleno, Karim, Nagi, Darlaine, Pétrin, Terence E, Hébert, Graciela, Pineyro   +5 more
openaire   +2 more sources

Régulation du complexe constitutif formé par le récepteur opioïde delta et le canal potassique de la famille Kir3

2015
Les opioïdes sont les analgésiques les plus efficaces dans le traitement des douleurs sévères. Ils produisent leurs effets en ciblant spécifiquement les récepteurs opioïdes localisés tout le long de la voie de perception de la douleur où ils modulent la transmission de l'information douloureuse.
openaire   +1 more source

Expressionsklonierung von heptahelikalen Rezeptoren durch Kopplung an G-Protein regulierte Einwärtsgleichrichter aus der Kir3-Familie.

1998
openaire   +1 more source