Results 211 to 220 of about 571,004 (286)

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

High-quality draft genome sequence of <i>Cryobacterium</i> sp. AP23 isolated from ancient Alaskan permafrost. [PDF]

Microbiol Resour Announc
Lemus-Cisneros HC, Barbato RA, McCarthy A, Blisard SN, Compton JR, Faber Q, Leary D, Roman VA, Stamps BW.   +8 more
europepmc   +1 more source

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

Comparative ASCL1 Interactome Analysis Reveals CDK2-Cyclin A2 as Suppressors of Differentiation in MYCN-Amplified Neuroblastoma. [PDF]

Mol Cancer Res
Mykhaylechko L, Gomez RL, Woods LM, Papachristou EK, Ramachandran R, Lundie-Brown J, Drummond R, Marcos D, Abou Grealy FMY, Ibragimova S, Ali FR, Carroll J, Philpott A.   +12 more
europepmc   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

Isolation of <i>Leishmania infantum</i> from a red fox (<i>Vulpes vulpes</i>) and vector competence of <i>Phlebotomus perniciosus</i>. [PDF]

One Health
Bezerra-Santos MA, Carbonara M, Fagundes-Moreira R, Camarda A, Volf P, Dantas-Torres F, Otranto D.   +6 more
europepmc   +1 more source

Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma

Advanced Science, EarlyView.
SOX2 upregulates KAT7 in glioma stem cells, where KAT7 deposits H3K14 acetylation at the RAC2 promoter to activate RAC2 transcription. RAC2‐GTP subsequently promotes PAK1/2/3 phosphorylation, increasing tricarboxylic acid cycle flux and mitochondrial respiration to support glioblastoma malignancy.
Jilong Liu, Yanfei Sun, Yuehua Zhu, Guangjing Mu, Jiazheng Wang, Liangliang Wang, Feihu Zhao, Zhimin Zhao, Jian Wang, Ying He, Zheng Jiang, Xingang Li, Mingzhi Han, Bin Huang   +13 more
wiley   +1 more source

Phenotypic and Genotypic Analyses of Antimicrobial Resistance Patterns of <i>Staphylococcus aureus</i> Isolates From Outpatient Blood Samples in Mukuru Slum, Nairobi, Kenya. [PDF]

Can J Infect Dis Med Microbiol
Ogeto J, Mitema S, Aboge G, Mainga A, Moriasi G.   +4 more
europepmc   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Capturing the dynamics of STAT6 macrophage polarization using bioluminescence temporal signatures. [PDF]

Cell Syst
Zheng S, Chiang YH, Aldarondo D, Locke A, Gunaje J, Davis J, Fox ZR, Akpa BS, Wayne E.   +8 more
europepmc   +1 more source