Results 221 to 230 of about 571,004 (286)

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Diagnostic and Phylogenetic Insights into a Human Rabies Virus Isolate from Romania. [PDF]

Viruses
Vuta V, Gradinaru M, Hurmuzache M, Bărbuceanu F, Zamfir L, Moțiu R, Schmid L, Höper D, Calvelage S, Müller T, Freuling CM.   +10 more
europepmc   +1 more source

Prion‐Like Protein LENG8‐Mediated Nucleation Drives Stress Granule Assembly

Advanced Science, EarlyView.
LENG8 is a newly identified stress granule (SG) nucleator required for SG assembly. Following stress, nuclear LENG8 granules disassemble, allowing LENG8 to translocate into the cytoplasm and form independent nucleation foci. These foci fuse with canonical early G3BP1/TIA1 seeds via LENG8‐TIA1 binding to drive SG maturation.
Mingxing Zhang, Xin Wang, Yilan Teng, Zhicheng Wu, Jing Fan, Hongwen Zhu, Peng Dai   +6 more
wiley   +1 more source

Counteracting FOX proteins epigenetically control the herpesvirus lytic-latent balance. [PDF]

Nat Commun
Xiang Y, Yang X, Zhang J, Hou F, Deng Y, Fu H, Oh HS, Wang Q, Chen S, Sun Z, Das B, Yeo YY, Pesola JM, Sen P, Jiang S, Knipe DM, Coen DM, Pan D.   +17 more
europepmc   +1 more source

Short-interval variability and test-retest reliability of Alzheimer's disease plasma biomarkers in a clinically heterogenous cohort. [PDF]

Alzheimers Res Ther
Beament M, Wiltshire K, Belder CRS, Abel E, Hart M, Heslegrave AJ, Lunn MP, Rosa-Grilo M, Swann O, Schott JM, Zetterberg H, Fox NC, Keshavan A.   +12 more
europepmc   +1 more source

Effect of selection for behavior on the blood glucose level in foxes exposed to restriction stress. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Gulevich RG, Shikhevich SG, Shepeleva DV, Kharlamova AV.   +3 more
europepmc   +1 more source

Complete genome sequence of two skunk adenovirus strains identified in African pygmy hedgehogs in Germany. [PDF]

Microbiol Resour Announc
Morito HLE, Jesse ST, Runft S, Puff C, Baumgärtner W, Osterhaus ADME, Ludlow M.   +6 more
europepmc   +1 more source

Same-day tagmentation PCR-based whole genome sequencing of bacteriophage genomes from a single plaque without DNA extraction. [PDF]

Sci Rep
Fox B, Paulini K, Chahal J, Łypaczewski P.   +3 more
europepmc   +1 more source

Off-Target-Based Tumor Fraction Estimation from Targeted Sequencing Shows Concordance with Orthogonal Methods Across Advanced Solid Tumors. [PDF]

Int J Mol Sci
Hasenleithner SO, Rao S, Yu JQ, Tan Y, Sheriff F, Winn JS, Borghaei H, Edelman MJ, Giri A, Astsaturov I, Wasik M, Jost PJ, Fernandez SV.   +12 more
europepmc   +1 more source