Results 131 to 140 of about 184,541 (309)

Chlorhexidine and benzalkonium chloride: promising adjuncts in combating multidrug resistant Klebsiella pneumoniae in healthcare settings

BMC Infectious Diseases
Background Hospital-acquired infections caused by multidrug resistant (MDR) Klebsiella pneumoniae pose a significant global health threat. Effective antisepsis and disinfection protocols are mandatory to prevent these infections.
Amal F. Makled, Azza Z. Labeeb, Heba M. Moaz, Asmaa S. Sleem   +3 more
doaj   +1 more source

A Hanks‐type bacterial kinase, PknS, directly phosphorylates the alternative sigma factor EcfK to promote resistance to protist predation

The FEBS Journal, EarlyView.
The Xanthomonas citri Hanks‐type kinase PknS autophosphorylates and directly phosphorylates the alternative sigma factor EcfK at five residues. Besides the conserved residue T51 in the σ2 domain, phosphorylation of a residue in the linker between σ2 and σ4 is critical for EcfK activation by promoting its interaction with a positively charged pocket in ...
Lídia dos Passos Lima, Dev Sriranganadane, Daiane Laise da Silva, Natália C. Drebes Dörr, Enzo Breviglieri Sichi Mello, Caio Vinicius dos Reis, Rogério Ferreira Lourenço, José Felipe Teixeira da Silva Santos, Anita Salmazo, Brenno Wendler Miranda, Katlin B. Massirer, Rafael M. Couñago, Cristina E. Alvarez‐Martinez   +12 more
wiley   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Antibiogram and Molecular Characterization of Extended-Spectrum Beta-Lactamase-Producing Klebsiella pneumoniae in a Nigerian Teaching Hospital

Microbes, Infection and Chemotherapy
Background: Klebsiella pneumoniae is a gram-negative bacterium responsible for infections like urinary tract infections (UTIs) and is a leading cause of nosocomial infections in immunocompromised patients.
Olabisi Promise Lawal, Joshua Odunayo Babatunde , Sandra Owusu-Ansah, Chinaemerem Precious Ani, Abiodun Christopher Adegbesan, Hajara Hashim, Jenifer Chiagozie Okeke, Nyerovwo Charity Okei, Aimuanmwosa Andrew Igunma, Daniel Osezuwa Ubebe, Kingsley Ugonna Ugoagwu, Okabeonye Sunday Agbo, Charissa Favour Ani   +12 more
doaj   +1 more source

Double-carbapenem regimen, alone or in combination with colistin, in the treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae (CR-Kp) [PDF]

, 2017
Aloj, F., Castaldi, D., D'Abramo, A., De Angelis, M., Gizzi, F., Mascellino, M. T., Mastroianni, C. M., Oliva, Alessandra, Scorzolini, L., Storto, M., Vullo, V.   +10 more
core   +1 more source

Bacterial Extracellular Vesicles in the Pathogenesis and Treatment of Liver Diseases

Journal of Gastroenterology and Hepatology, EarlyView.
Liver diseases are a major global health challenge, with current treatments inadequate. This review highlights the role of bacterial extracellular vesicles in liver inflammation, fibrosis, and metabolism. We also explore these from commensals and probiotics, their protective effects, and discuss research challenges and future therapeutic potential ...
Yakun Li, Jia Li, Robin P. F. Dullaart, Han Moshage   +3 more
wiley   +1 more source

Microbiota and clinical outcomes of implant‐supported full‐mandible dentures on patients with a history of periodontitis: A 5‐year prospective cohort study

Journal of Prosthodontics, EarlyView.
Abstract Purpose To characterize the microbiota of implant‐supported full‐mandible dentures and its correlation to clinical outcomes for up to 5 years after implant loading in patients with a history of periodontal disease. Materials and Methods Twelve individuals with a history of periodontitis (Stage IV and Grade B) received five immediate implants ...
Jefferson Antônio Gomes, Yumi Chokyu Del‐Rey, Alice Ramos de Freitas, Ivete Aparecida de Mattias Sartori, Cássio do Nascimento   +4 more
wiley   +1 more source

Dissemination of Klebsiella pneumonia and Klebsiella oxytoca Harboring bla TEM genes isolated from different clinical samples in Erbil City

Diyala Journal of Medicine, 2018
Background: Klebsiella spp. is an opportunistic nosocomial pathogen causing a variety of infections including urinary tract infections, pneumonia, septicemia, wound infections, distributed between patient results from producing ESBL enzymes lead to ...
Fattma A Ali, Rozhan Mohammed Ismael
doaj   +2 more sources

Experimental phage therapy of burn wound infection : difficult first steps [PDF]

, 2014
Antibiotic resistance has become a major public health problem and the antibiotics pipeline is running dry. Bacteriophages (phages) may offer an ‘innovative’ means of infection treatment, which can be combined or alternated with antibiotic therapy and ...
De Vos, Daniel, Jennes, Serge, Lavigne, Rob, Merabishvili, Maia, Pirnay, Jean Paul, Rose, Thomas, Vaneechoutte, Mario, Verbeken, Gilbert, Zizi, Martin   +8 more
core  

Antimicrobial Resistance and Infant Mortality in Sri Lanka: A Retrospective Cohort Study

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Objective Sepsis is a major cause of mortality among children, with the highest burden evident in neonates and young infants, particularly, in resource‐constrained healthcare settings. Despite this burden, there are insufficient published data to delineate the epidemiology of neonatal sepsis from many of these settings.
Gayana P. S. Gunaratna, Michelle L. Harrison, Benjamin F. R. Dickson, Rajeev Sathanandaraja, T. M. Ruwanthi Perera, Nambage Shirani Chandrasiri, Anasuya Sutharson, Jannah Baker, Phoebe C. M. Williams   +8 more
wiley   +1 more source