Results 51 to 60 of about 270,953 (191)

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Diagnosis of bacteraemia in neonatal foals using 16S rRNA high‐throughput sequencing

Equine Veterinary Journal, EarlyView.
Abstract Background Sepsis is an important cause of morbidity and mortality in foals. Early diagnosis can improve outcome but is complicated by non‐specific clinical signs and delayed confirmation of infection via blood culture. Molecular assays represent a rapid and more sensitive alternative.
Flavie Payette, Alicia E. Long, Weiming Hu, Kyle Bittinger, Ahmed M. Moustafa, Darko Stefanovski, Michelle Abraham, Maia R. Aitken   +7 more
wiley   +1 more source

Microbiological etiologies of pneumonia complicating stroke: A systematic review [PDF]

, 2018
Background and Purpose—Identifying the causal pathogens of pneumonia complicating stroke is challenging, and antibiotics used are often broad spectrum, without recourse to the microbiological cause.
Kishore, Amit K., Chamorro, Angel, Smith, Craig J, Jeans, Adam R., Langhorne, Peter, Mark Woodhead, Craig J. Smith, Amit K. Kishore, Lalit Kalra, Vail, Andy, Kishore, Amit, Peter Langhorne, van de Beek, Diederik, Diederik van de Beek, Joan Montaner, Nederkoorn, Paul J, Woodhead, Mark, Christine Roffe, Nederkoorn, Paul J., Westendorp, Willeke, Andreas Meisel, Vail, Andy; id_orcid, Andy Vail, van-de-Beek, Diederik, Smith, Craig J., Roffe, Christine, Paul J. Nederkoorn, Mario Di Napoli, Willeke Westendorp, Beek, Diederik van de, Montaner, Joan, Di Napoli, Mario, Kalra, Lalit, null null, Meisel, Andreas, Di-Napoli, Mario, Adam R. Jeans, Javier Garau, Kishore, Amit K, Angel Chamorro, Smith, Craig, Garau, Javier, Jeans, Adam R   +42 more
core   +1 more source

Crystal structure of ChbG from Klebsiella pneumoniae reveals the molecular basis of diacetylchitobiose deacetylation

Communications Biology, 2022
Structural and functional characterization of Klebsiella pneumonia ChbG (which lacks sequence homology) reveals the mechanism of chitooligosaccharide processing by ChbG.
So Yeon Lee, Bashu Dev Pardhe, Tae-Jin Oh, Hyun Ho Park   +3 more
doaj   +1 more source

The Preparation of Novel Fluorenes Inspired by Hipposudoric Acid

Helvetica Chimica Acta, EarlyView.
In this research we report on the design and synthesis of a series of fluorene‐based derivatives loosely inspired by the tricyclic framework of hipposudoric acid. Preparation of sixteen novel N‐alkylated derivatives was accomplished via a series of concise one‐step amide N‐alkylation reactions.
Munib Uddin, Freya Harrison, Florida Koçi, Stephen P. Wren   +3 more
wiley   +1 more source

Ultrasonik sistemlerle suda klebsiella pneumonia dezenfeksiyonu [PDF]

, 2014
Tez (yüksek lisans) - Anadolu ÜniversitesiAnadolu Üniversitesi, Fen Bilimleri Enstitüsü, Çevre Mühendisliği Anabilim DalıKayıt no: 1035526Günümüzde bulaşıcı hastalıkların önüne geçilmesi amacıyla uygulanan dezenfeksiyon işlemleri içme ve kullanma suyu ...
Karaer, Fadime
core   +2 more sources

Myeloid-related protein-14 contributes to protective immunity in gram-negative pneumonia derived sepsis.

PLoS Pathogens, 2012
Klebsiella (K.) pneumoniae is a common cause of pneumonia-derived sepsis. Myeloid related protein 8 (MRP8, S100A8) and MRP14 (S100A9) are the most abundant cytoplasmic proteins in neutrophils.
Ahmed Achouiti, Thomas Vogl, Constantin F Urban, Marc Röhm, Tijmen J Hommes, Marieke A D van Zoelen, Sandrine Florquin, Johannes Roth, Cornelis van 't Veer, Alex F de Vos, Tom van der Poll   +10 more
doaj   +1 more source

Monocyte inflammation and adaptive immune dysfunction in severe Klebsiella pneumoniae pneumonia

iMeta, EarlyView.
Severe Klebsiella pneumoniae pneumonia combines intense inflammation with failure to control infection, yet the cellular basis is unclear. Using a severity‐focused single‐cell atlas of 708,894 peripheral blood mononuclear cells from 100 individuals, complemented by plasma protein measurements and flow cytometry, we show that disease severity redirects ...
Hongquan Chen, Xiaoling Wang, Xiang Liu, Kui Dong, Yanying Feng, Min Yuan, Shiyi Wang, Fangfang Fan, Yong Tian, Zhiming Kang, Xiushuai Du, Chaolu Hasi, Hong Lu, Wei Guan, Xu Chen, Mengyu Cheng, Wei Wei, Nan Guo, Zhiguo Liu, Xiaotong Qiu, Yiwei Shi, Kun Xiao, Yi Wang, Zhenjun Li   +23 more
wiley   +1 more source

Isolation and Characterization of Hydrocarbon-utilizing Bacteria from Petroleum Sludge Samples obtained from Crude Oil Processing Facility in Nigeria

Journal of Applied Sciences and Environmental Management, 2017
The isolation and characterization of hydrocarbon-utilizing bacteria from petroleum oily sludge collected from crude oil processing plant in Rivers State, Nigeria was carried out.
Vincent C. Wokem, Lucky O. Odokuma, Caroline N. Ariole   +2 more
doaj   +1 more source

Protective multi-epitope candidate vaccine for urinary tract infection

Biotechnology Reports, 2020
Urinary tract infections (UTIs) are induced by exogenous organisms including extraintestinal pathogenic such as Escherichia coli (ExPEC), Proteus mirabilis and Klebsiella pneumonia, which are closely related.
Mana Oloomi, Maryam Javadi, Mohammad Reza Asadi Karam, Jamil Kheirvari Khezerloo, Zohreh Haghri, Saeid Bouzari   +5 more
doaj   +1 more source