Results 101 to 110 of about 54,134 (244)
NaNog: A pluripotency homeobox (master) molecule. [PDF]
, 2015 One of the most intriguing aspects of cell biology is the state of pluripotency, where the cell is capable of self-renewal for as many times as deemed necessary , then at a specified time can differentiate into any type of cell. This fundamental process
Aguib, YE +4 more
core +1 more source
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
Regenerative Therapy, 2019 Introduction: Krüppel-like factor 4 (KLF4) is considered one of the Yamanaka factors, and recently, we and others have shown that KLF4 is one of the transcription factors essential for reprogramming non-human corneal epithelial cells (HCECs) into HCECs ...
Satoko Fujimoto +6 more
doaj +1 more source
Regenerative Medicine for the Aging Brain [PDF]
, 2014 In the central nervous system, cholinergic and dopaminergic (DA) neurons are among the cells most susceptible to the deleterious effects of age. Thus, the basal forebrain cholinergic system is known to undergo moderate neurodegenerative changes during ...
Goya, Rodolfo Gustavo +3 more
core +2 more sources
KLF4 Genome: A double edged sword
Journal of Solid Tumors, 2015 Kruppel like factor 4 (KLF4), member of SP1/KLF transcription factor family is characterized by three extremely conserved C2H2-type zinc-finger motifs at its carboxyl boundary that are crucial for its interaction with target DNA. Participation of KLF4 in the control of proliferation, differentiation and apoptosis are suggestive for KLF4 critical role ...
Deepti Malik, Deepak Kaul
openaire +2 more sources
Interdisciplinary Medicine, EarlyView.Sleep deprivation accelerates the progression of MASLD and IR by up‐regulating the expression of miR‐3572‐5p and down‐regulating the expression of miR‐183‐5p in circulating exosomes, thereby inhibiting fatty acid β‐oxidation and disrupting insulin signaling pathways. Abstract Sleep deprivation (SD) threatens human health and increases the prevalence of
Xinxin Xu +10 more
wiley +1 more source
KLF4 Expression Correlates with the Degree of Differentiation in Colorectal Cancer
Gut and Liver, 2011 Background/AimsKr?ppel-like factor 4 (KLF4) is an epithelial-specific transcription factor primarily expressed in the gastrointestinal tract that mediates growth arrest in the colonic epithelium.
doaj +1 more source
Breast Cancer Research, 2020 Background Triple-negative breast cancer (TNBC) is characterized by high rates of recurrence and poor overall survival. This is due, in part, to a deficiency of targeted therapies, making it essential to identify therapeutically targetable driver ...
Melyssa S. Roberts +8 more
doaj +1 more source
Med Research, EarlyView.ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang +22 more
wiley +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: Inflammation is an essential component of innate immunity against pathogens, but is tightly regulated, such as by Krüppel-like factor 4 (Klf4), to prevent injury.
Zhenzhen Li +8 more
doaj +1 more source