Results 171 to 180 of about 59,892 (236)

In Vivo Chemical Reprogramming Is Associated With a Toxic Accumulation of Lipid Droplets Hindering Rejuvenation

Aging Cell, Volume 25, Issue 2, February 2026.
Partial chemical reprogramming significantly increases mitochondrial interaction networks, affects mitochondrial morphology, speeds up mitochondrial movement dynamics, increases mitochondrial transmembrane potential, and induces TCA cycle stress. These changes in mitochondrial function contribute to lipid droplet accumulation, acute kidney injury, and ...
Wayne Mitchell, Cecília G. de Magalhães, Alexander Tyshkovskiy, Yushi Uchida, Ludger J. E. Goeminne, Takaharu Ichimura, Emery L. Ng, Alibek Moldakozhayev, Joseph V. Bonventre, Vadim N. Gladyshev   +9 more
wiley   +1 more source

Distinct Roles of IL‐4, IL‐13, and IL‐22 in Human Skin Barrier Dysfunction and Atopic Dermatitis

Allergy, Volume 81, Issue 2, Page 480-497, February 2026.
This study reports the distinct effects of IL‐4, IL‐13, and IL‐22 on bio‐stabilized human skin with intact barriers and immune cells. IL‐4, IL‐13, and IL‐22 upregulate inflammatory mediators, disrupt skin barrier integrity, and reciprocally modulate IL‐4Rα and IL‐22Rα1 receptors.
Paolo D'Avino, Juno Kim, Manru Li, Philipp Gessner, Patrick Westermann, Yagız Pat, Carina Beha, Claudia Traidl‐Hoffmann, Jeremy Bost, Nicolas Gaudenzio, Christoph B. Messner, Cezmi A. Akdis, Yasutaka Mitamura   +12 more
wiley   +1 more source

LncRNA H19‐Encoded Micropeptide altH19 Promotes DNA Replication and Mitosis in Myeloma Cells by Enhancing the Phosphorylation of CDK2 at Threonine 160

Cell Proliferation, Volume 59, Issue 2, February 2026.
The micropeptide altH19 interacts with phosphorylated CDK2 (p‐CDK2), subsequently activating CDK2 phosphorylation. This enhances the downstream E2F1 target gene RB activity, which accelerates DNA replication, ultimately leading to rapid myeloma cell mitosis and proliferation.
Yaxin Zhang, Wenjing Li, Xu Cao, Jiwei Mao, Xiaodan Zhou, Linlin Liu, Ruosi Yao   +6 more
wiley   +1 more source

Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

Cell Proliferation, Volume 59, Issue 2, February 2026.
Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie, Ting Wang, Xin‐ran Liu, Yan Wang, Qin Dang, Tian Ding, Jia‐qi Xu, Xian‐jun Yu, Hai Lin, Xiao‐wu Xu, Yi Qin   +10 more
wiley   +1 more source

Exosomal HMGB1 Orchestrates NSCLC Progression and Immunosuppressive Macrophage Polarisation Through the TLR4/NF‐κB/IL‐6/STAT3 Signalling Cascade

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT High mobility group box 1 (HMGB1), a prototypical alarmin and chromatin‐binding protein, has emerged as a critical mediator of tumour‐associated inflammation and immune regulation. Although its soluble form has been implicated in various malignancies, the functional contribution of HMGB1 encapsulated within exosomes remains incompletely ...
Jia‐Ru Huang, Wen‐Chao Gu, Ya‐Ping Yuan, Jun‐Xia Yang, Yan Chen, Xiao‐Xia Guo, Wei Ding   +6 more
wiley   +1 more source

Zinc‐Mediated Lysosomal Destabilization Links Mitochondrial Damage to Neuronal Death in a Cellular MPP+ Model of Parkinson's Disease

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
When mitochondria are damaged by MPP+, they produce excess reactive oxygen species (ROS) and release zinc (Zn2+) inside the cell. This surge in zinc overwhelms lysosomes—the cell's major zinc‐buffering organelles—causing their membranes to break down. Leaking lysosomal enzymes then trigger neuronal death. Treatments that reduce ROS, bind zinc, or block
Hyun‐Seung Lee, Sun‐Ah Kang, Jae‐Won Eom, Min Seong Kim, Ji‐Soo Kim, Yang‐Hee Kim   +5 more
wiley   +1 more source

Roles of KLF4 and AMPK in the inhibition of glycolysis by pulsatile shear stress in endothelial cells

Proceedings of the National Academy of Sciences of the United States of America, 2021
Yue Han, M. He, Traci L. Marin, Hui Shen, Wei-Ting Wang, Tzong-Yi Lee, Hsiao-Chin Hong, Zong-Lai Jiang, T. Garland, J. Shyy, Brendan Gongol, S. Chien   +11 more
semanticscholar   +1 more source

Sentrin-specific protease 3 (SENP3)-mediated Krüppel-like factor 4 (KLF4) deSUMOylation regulates vascular smooth muscle cell phenotypic switching in atherosclerosis. [PDF]

Mol Biomed
Wang Z, Wang Y, Yuan R, Ji Q, Li Y, Huo H, Zhou G, Yan X, Shen L, Cai Z, He B.   +10 more
europepmc   +1 more source

Recent trend on sarcoma stem cell reprogramming towards study of disease progression: A systematic review. [PDF]

J Stem Cells Regen Med
Zulkifli NS, Ab-Rahim S, Muhamad M.
europepmc   +1 more source

Clinicopathological Significance of Pluripotent Factors in Sinonasal Intestinal-Type Adenocarcinoma. [PDF]

Cancers (Basel)
Monaco F, Vallieri A, Volpini L, Foschini MP, Filosa A, Antolini E, Gioacchini FM, Sollini G, Pasquini E, Iannella G, Neuzil J, Amati M, Santarelli L, Tomasetti M, Re M.   +14 more
europepmc   +1 more source