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The Lancet, 2000
Klinefelter’s syndrome (KS) is the most common sex chromosome disorder in men, affecting roughly 1 in 400–600 men throughout all ethnic groups (1,2) It is also the most common cause of primary testicular failure, resulting in impairments in both spermatogenesis and testosterone production.
Paulsen, C. Alvin +3 more
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Klinefelter’s syndrome (KS) is the most common sex chromosome disorder in men, affecting roughly 1 in 400–600 men throughout all ethnic groups (1,2) It is also the most common cause of primary testicular failure, resulting in impairments in both spermatogenesis and testosterone production.
Paulsen, C. Alvin +3 more
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BMJ, 2012
A 29 year old man presented to primary care with anxiety and depression that had worsened since childhood. Further questioning revealed a history of poor school performance, poor body image, and poor self esteem. On physical examination, the patient’s height was 189 cm and he had narrow shoulders, wide hips, sparse facial hair (which he shaved once ...
Christopher H, Blevins +1 more
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A 29 year old man presented to primary care with anxiety and depression that had worsened since childhood. Further questioning revealed a history of poor school performance, poor body image, and poor self esteem. On physical examination, the patient’s height was 189 cm and he had narrow shoulders, wide hips, sparse facial hair (which he shaved once ...
Christopher H, Blevins +1 more
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Klinefelter Syndrome and Turner Syndrome
Pediatrics In Review, 20211. Carole Samango-Sprouse, EdD*,†,‡ 2. Sophia Q. Song, BA‡ 3. Angela E. Lin, MD§ 4. Cynthia M. Powell, MD¶ 5. Andrea L. Gropman, MD*,** 1. *George Washington University, Washington, DC 2. †Florida International University, Miami, FL 3. ‡Department of Research, The Focus Foundation, Davidsonville, MD 4.
Carole, Samango-Sprouse +4 more
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Best Practice & Research Clinical Endocrinology & Metabolism, 2011
Klinefelter syndrome (KS) is the most common genetic form of male hypogonadism, but overt phenotype becomes evident only after puberty. During childhood, and even during early puberty, pituitary-gonadal function in 47,XXY subjects is relatively normal, but from midpuberty onwards, FSH and LH levels increase to hypergonadotropic levels, inhibin B ...
Anne M, Wikström, Leo, Dunkel
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Klinefelter syndrome (KS) is the most common genetic form of male hypogonadism, but overt phenotype becomes evident only after puberty. During childhood, and even during early puberty, pituitary-gonadal function in 47,XXY subjects is relatively normal, but from midpuberty onwards, FSH and LH levels increase to hypergonadotropic levels, inhibin B ...
Anne M, Wikström, Leo, Dunkel
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Spermatogenesis in Klinefelter syndrome
Journal of Endocrinological Investigation, 2010Klinefelter syndrome (KS) (47,XXY) is the most common sex chromosomal disorder, and it is a frequent form of male hypogonadism and infertility. Although the majority of these patients are azoospermic, they might have severe oligozoospermia or residual single-residual foci with spermatogenesis in the testis.We report our experience on sperm retrieval in
SELICE R +6 more
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Screening for Klinefelter syndrome
Current Opinion in Endocrinology, Diabetes & Obesity, 2015To examine recently published evidence that may inform the need for population screening of Klinefelter syndrome; by far the most common chromosomal disorder in males, which most often escapes diagnosis throughout the lifespan.Research regarding the prevalence and characteristics of developmental and learning difficulties in Klinefelter syndrome ...
Amy S, Herlihy, Robert I, McLachlan
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Osteoporosis and Klinefelter's syndrome
Bone and Mineral, 1990Summary objective We wanted to measure forearm mineral density and bone‐related biochemical variables in patients with Klinefelter's syndrome. design Measurements made in patients with Klinefelter's syndrome were compared to those obtained in age‐matched normal male volunteers. patients We studied 22 patients with Klinefelter's syndrome (12 of whom had
M, Horowitz +5 more
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KLINEFELTER SYNDROME IN THE AGED
Age and Ageing, 1977Three cases of Klinefelter syndrome diagnosed late in life are reported with the clinical and post-mortem findings. The diagnosis was suspected owing to the absence of testes and the presence of associated varied clinical features. The urinary follicle-stimulating hormone levels were not elevated and were very low in two of the cases. Bronchopneumonia,
A N, Clark, M S, Zuha
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The Pituitary in Klinefelter Syndrome
Endocrine Pathology, 2005Klinefelter syndrome is a genetically determined primary gonadal defect characterized by the XXY karyotype. The testes are small, blood testosterone levels are low, and blood gonadotropin levels are elevated. Pituitary changes in patients with Klinefelter syndrome have not been evaluated in detail.The first patient, a 76-yr-old man, was operated for a ...
B W, Scheithauer +5 more
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Klinefelter Syndrome and Diabetes
Current Diabetes Reports, 2019Klinefelter syndrome (KS) is associated with increased insulin resistance and high rates of type 2 diabetes (T2DM). Our aim was to review what is known about the prevalence of diabetes in men with KS, potential mechanisms underlying the observed metabolic phenotype, and the data that are available to guide treatment decisions.The increased prevalence ...
Mark J, O'Connor +2 more
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