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21527. LA HETEROCIGOSIDAD KLOTHO-VS MITIGA LOS EFECTOS DE APOE-ɛ4 EN LA ATROFIA DEL HIPOCAMPO
Ling Zhang +7 more
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Expression and clinical significance of Klotho protein in serum, umbilical cord blood, and placenta of pregnant women with intrauterine growth restriction. [PDF]
Front PediatrZeng G, Lian J, Shen J, Shi Y.
europepmc +1 more source
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FGF23 and klotho at the intersection of kidney and cardiovascular disease
Nature Reviews Cardiology, 2023Daniel L Edmonston +2 more
exaly +2 more sources
The Klotho proteins in health and disease
Nature Reviews Nephrology, 2018Makoto Kuro-O
exaly +2 more sources
Klotho converts canonical FGF receptor into a specific receptor for FGF23
Nature, 2006Toshiro Fujita, Seijii Fukumoto
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Pflügers Archiv - European Journal of Physiology, 2009
The klotho gene was identified as an "aging-suppressor" gene in mice that accelerates aging when disrupted and extends life span when overexpressed. It encodes a single-pass transmembrane protein and is expressed primarily in renal tubules. The extracellular domain of Klotho protein is secreted into blood and urine by ectodomain shedding. The two forms
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The klotho gene was identified as an "aging-suppressor" gene in mice that accelerates aging when disrupted and extends life span when overexpressed. It encodes a single-pass transmembrane protein and is expressed primarily in renal tubules. The extracellular domain of Klotho protein is secreted into blood and urine by ectodomain shedding. The two forms
openaire +2 more sources