Results 291 to 300 of about 33,787 (326)
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Lipids in Health and Disease
Objective To investigate the relationship between uric acid to high-density lipoprotein cholesterol ratio (UHR) and circulating α-klotho levels in U.S. adults.
Xuanchun Huang +5 more
semanticscholar +1 more source
Objective To investigate the relationship between uric acid to high-density lipoprotein cholesterol ratio (UHR) and circulating α-klotho levels in U.S. adults.
Xuanchun Huang +5 more
semanticscholar +1 more source
American Journal of Nephrology, 2023
Introduction: This study aimed to investigate the relationship between circulating soluble Klotho concentration and all-cause mortality in individuals with chronic kidney disease (CKD).
Shisheng Han +5 more
semanticscholar +1 more source
Introduction: This study aimed to investigate the relationship between circulating soluble Klotho concentration and all-cause mortality in individuals with chronic kidney disease (CKD).
Shisheng Han +5 more
semanticscholar +1 more source
Soluble Klotho and Incident Hypertension
Clinical Journal of the American Society of Nephrology, 2021Background and objectives Hypertension is associated with significant morbidity and mortality despite effective antihypertensive therapies. Soluble klotho is a circulating protein that in preclinical studies is protective against the development of hypertension. There are limited studies of klotho and blood pressure in humans.
David A. Drew +11 more
openaire +2 more sources
Klotho protein deficiency and aging
Geriatrics & Gerontology International, 2010Aging is inevitable; however, the molecular mechanism of aging has not been fully elucidated. Investigations into aging are facing difficulties because aging is influenced by complex factors such as circumstances, living habits and genetic background.
Hiroshi, Manya +2 more
openaire +2 more sources
2012
Endocrine fibroblast growth factors (FGFs) have been recognized as hormones that regulate a variety of metabolic processes. FGF19 is secreted from intestine upon feeding and acts on liver to suppress bile acid synthesis. FGF21 is secreted from liver upon fasting and acts on adipose tissue to promote lipolysis and responses to fasting. FGF23 is secreted
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Endocrine fibroblast growth factors (FGFs) have been recognized as hormones that regulate a variety of metabolic processes. FGF19 is secreted from intestine upon feeding and acts on liver to suppress bile acid synthesis. FGF21 is secreted from liver upon fasting and acts on adipose tissue to promote lipolysis and responses to fasting. FGF23 is secreted
openaire +2 more sources
Nihon rinsho. Japanese journal of clinical medicine, 2004
The klotho gene, originally identified by insertional mutagenesis in mice, suppresses multiple aging phenotypes(e.g. arteriosclerosis, pulmonary emphysema, osteoporosis, infertility, short lifespan). We have shown that mice deficient for the klotho gene show endothelial dysfunction as manifested by an attenuated response of aortic relaxation in ...
Yuichiro, Saito +2 more
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The klotho gene, originally identified by insertional mutagenesis in mice, suppresses multiple aging phenotypes(e.g. arteriosclerosis, pulmonary emphysema, osteoporosis, infertility, short lifespan). We have shown that mice deficient for the klotho gene show endothelial dysfunction as manifested by an attenuated response of aortic relaxation in ...
Yuichiro, Saito +2 more
openaire +1 more source
Klotho-Dependent Cellular Transport Regulation
2016Klotho is a transmembrane protein that in humans is encoded by the hKL gene. This protein is known to have aging suppressor effects and is predominantly expressed in the distal convoluted tubule of the kidney, parathyroid glands, and choroid plexus of the brain.
M, Sopjani, M, Dërmaku-Sopjani
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Science's STKE, 2006
A remarkable range of biological functions and mechanisms of action have been proposed for the protein Klotho. Klotho is a membrane protein with a large extracellular domain. However, its cytoplasmic domain includes just 11 amino acids, which are thought to be unlikely to mediate its regulatory functions.
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A remarkable range of biological functions and mechanisms of action have been proposed for the protein Klotho. Klotho is a membrane protein with a large extracellular domain. However, its cytoplasmic domain includes just 11 amino acids, which are thought to be unlikely to mediate its regulatory functions.
openaire +1 more source
2021
During the evolution of skeletons, vertebrates acquired the bone made of calcium phosphate. By keeping the extracellular fluid in a supersaturated condition regarding calcium and phosphate, vertebrates create the bone when and where they want simply by providing a cue for precipitation.
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During the evolution of skeletons, vertebrates acquired the bone made of calcium phosphate. By keeping the extracellular fluid in a supersaturated condition regarding calcium and phosphate, vertebrates create the bone when and where they want simply by providing a cue for precipitation.
openaire +2 more sources