Results 41 to 50 of about 100,878 (312)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Associations of Sleep and Shift Work With Osteoarthritis Risk

Arthritis Care &Research, EarlyView.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships among circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000–person cohort, we evaluated associations among sleep duration, sleeplessness/insomnia, and shift
Elizabeth L. Yanik, Abigail Bridgeman, Erik D. Herzog, Vy Pham, Bradley A. Evanoff, Farshid Guilak   +5 more
wiley   +1 more source

Minimal Important Change and Minimal Clinically Important Difference in Pain and Function With Exercise in Hip Osteoarthritis

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to estimate the minimal important change (MIC) and minimal clinically important difference (MCID) for pain and physical function in individuals with hip osteoarthritis (OA) following a physiotherapist‐guided exercise intervention.
Yareni Guerrero, Fiona Dobson, Venkatesha Venkatesha, Kim Allison, Gabrielle Knox, Libby Spiers, Travis Haber, David J Hunter, Michelle Hall   +8 more
wiley   +1 more source

MRI of the posterolateral corner of the knee, please have a look

Alexandria Journal of Medicine, 2017
The knee PLC injuries are frequently seen, with other major knee injuries, such as ACL and PCL. Objective: This article aimed to clarify PLC injuries that could be diagnosed by MRI, and may have an impact on the management of the associated major knee ...
Mahmoud Agha
doaj   +1 more source

Knee pain [PDF]

, 2006
JC is a 13 year old boy who presented with a 3 week history of anterior right knee pain. Pain is activity related and brought on whenever JC plays football or basketball. He never needed to stop from any particular activity because of the pain.
Formosa, Aaron
core  

Tibiofemoral and patellofemoral joint 3D-kinematics in patients with posterior cruciate ligament deficiency compared to healthy volunteers [PDF]

, 2012
Background: The posterior cruciate ligament (PCL) plays an important role in maintaining physiological kinematics and function of the knee joint. To date mainly in-vitro models or combined magnetic resonance and fluoroscopic systems have been used for ...
Ulrich Lenze, Thomas Stein, Pohlig, Florian, Frederic Welsch, Florian Pohlig, Graichen, Heiko, Lenze, Ulrich, Stefan Hinterwimmer, Heiko Graichen, Rainer Burgkart, Burgkart, Rainer, Ruediger von Eisenhart-Rothe, Eisenhart-Rothe, Rüdiger von, Hinterwimmer, Stefan, Stein, Thomas, Welsch, Frederic   +15 more
core   +1 more source

Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow‐Up: Data From the Multicenter Osteoarthritis Study

Arthritis Care &Research, EarlyView.
Objective Obesity, defined by body mass index (BMI) ≥30 kg/m2, is a risk factor for functional limitations in people with knee osteoarthritis (OA). However, function varies among such individuals. Our objective was to evaluate the implications of obesity subtypes on longitudinal patterns of physical functioning in people with or at risk for knee OA ...
Kristine Godziuk, Sarah Tilley, Michael LaValley, Michael C. Nevitt, Cora E. Lewis, James C. Torner, Tuhina Neogi, for the Multicenter Osteoarthritis Study Group   +7 more
wiley   +1 more source

Whole body kinematics and knee moments that occur during an overhead catch and landing task in sport [PDF]

, 2012
Background: Athletes suffering an anterior cruciate ligament injury tend to exhibit similar body postures that in sidestep cutting are associated with increased knee moments. This relationship, however, has not been investigated in landing.
Dempsey, A.R., Munro, B.J., Elliott, B.C., Lloyd, D.G., Steele, J.R.   +4 more
core   +1 more source

Clinical Management of Ligament Injuries of the Knee and Postoperative Rehabilitation [PDF]

, 2016
Ligament injuries of the knee are common and occur via a variety of mechanisms. The medial collateral ligament is most commonly injured but injury to the anterior cruciate ligament is most often highlighted in the media due to its prevalence in sports ...
Fu, Freddie H., Sebastián Irarrázaval, Freddie H. Fu, D. Guenther, Irarrázaval Domínguez, Sebastián, Yaseen, Z., Guenther, D., Z. Yaseen   +7 more
core   +1 more source

Longitudinal Changes in Adiposity after a Youth Sport‐Related Knee Injury: Informing Post‐Traumatic Osteoarthritis Prevention

Arthritis Care &Research, Accepted Article.
Objective Youth who experience a sport‐related knee injury have elevated odds of overweight or obesity in 3‐10 years, compounding their risk for post‐traumatic osteoarthritis (PTOA). To inform prevention strategies, this study compared patterns of adiposity change between youth with a sport‐related knee injury and uninjured youth in the 2‐year period ...
Justin M. Losciale, Nuria EJ Jansen, Christina Y. Le, Leo Lu, Hui Xie, Marienke van Middelkoop, Jackie L. Whittaker   +6 more
wiley   +1 more source