Results 81 to 90 of about 3,037,337 (268)

SEVERE CRUSHING INJURIES TO THE KNEE JOINT [PDF]

open access: yesSouthern Medical Journal, 1915
n ...
openaire   +1 more source

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

open access: yesAdvanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng   +7 more
wiley   +1 more source

Cellular and molecular response to mechanical articular cartilage injury [PDF]

open access: yes, 2010
PhDJoint injures frequently involve structural damage to articular cartilage and the underlying subchondral bone. The outcome of acute joint surface defects (JSD) varies from spontaneous healing to the development of post-traumatic osteoarthritis (PTOA).
Eltawil, Noha
core   +3 more sources

Combined Anatomical Arthroscopic Posterior Cruciate Ligament and Posterolateral Corner Reconstruction Using a Knotless Anchor: A Simplified Approach

open access: yesArthroscopy Techniques
Posterior cruciate ligament injuries are commonly associated with the knee joint posterolateral corner injury. Many open surgical techniques have been described in the literature to restore knee joint stability, including reconstruction of the posterior ...
Ali Alayane, M.D.   +4 more
doaj   +1 more source

Dislocation of the fibular head in an unusual sports injury: a case report

open access: yesJournal of Medical Case Reports, 2008
Introduction One of the primary functions of the proximal tibiofibular joint is slight rotation to accommodate rotational stress at the ankle. Proximal tibiofibular joint dislocation is a rare injury and accounts for less than 1% of all knee injuries ...
Ahmad Riaz, Case Ruth
doaj   +1 more source

Metabolic‐Redox Remodeling of Inflammatory Synovium by Mannose‐Modified Selenium Nanoparticles for Osteoarthritis Therapy

open access: yesAdvanced Science, EarlyView.
Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Yu‐Qing Zou   +15 more
wiley   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

open access: yesAdvanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao   +7 more
wiley   +1 more source

Injury Risk Estimation Expertise: Interdisciplinary Differences in Performance on the ACL Injury Risk Estimation Quiz [PDF]

open access: yes, 2015
Background: Simple observational assessment of movement is a potentially low-cost method for anterior cruciate ligament (ACL) injury screening and prevention.
Cokely, E.   +11 more
core   +1 more source

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