Results 161 to 170 of about 145,744 (313)

The Potential Role of Synovial T Cell Infiltration Following Knee Joint Injury in Symptoms and Progression to Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Identification of osteoarthritis (OA)–specific synovial inflammatory pathways and their temporal relevance is critical for therapeutic targeting. We compared mononuclear inflammatory/immune cell responses following joint injury that does or does not lead to OA to define bona fide OA‐associated cellular events.
Babak Moradi, Miriam T. Jackson, Cindy C. Shu, Susan M. Smith, Margaret M. Smith, Sanaa Zaki, Hadrian Platzer, Nils Rosshirt, David Giangreco, Carla R. Scanzello, Christopher B. Little   +10 more
wiley   +1 more source

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

Machine learning analysis of FOSL2 and RHoBTB1 as central immunological regulators in knee osteoarthritis synovium

Journal of International Medical Research
Background Knee osteoarthritis is a debilitating disease with a complex pathogenesis. Synovitis, which refers to inflammation of the synovial membrane surrounding the joint, is believed to play an important role in the development and progression of knee
Kun Gao, Zhenyu Huang, Zhouwei Liao, Yanfei Wang, Dayu Chen   +4 more
doaj   +1 more source

Behavioral Incentives for Exercise and Intra‐Articular Glucocorticoids for Knee Osteoarthritis: Results From a Factorially Designed Pragmatic Randomized Clinical Trial

Arthritis &Rheumatology, EarlyView.
Objective The purpose of this study was to determine the benefit of a behaviorally designed incentive program and glucocorticoid injections in reducing symptoms and promoting physical activity in patients with knee osteoarthritis (KOA). Methods This was a pragmatic, multisite, factorially designed, blinded, randomized clinical trial.
Joshua F. Baker, Katherine D. Wysham, Mercedes Quinones, Bryant R. England, Kaitian Jin, Marianna Olave, Sarah Wetzel, Rachel L. Gillcrist, Criswell Lavery, Natalie Keller, Bridget Kramer, Bibianna Ateh, Hannah Brubeck, Daniel K. White, Alexis Ogdie, Rui Xiao, Tuhina Neogi, Carla R. Scanzello   +17 more
wiley   +1 more source

Autoantibodies to Joint‐Related Peptides Are Associated With Onset of Rheumatoid Arthritis in Presymptomatic Seronegative Individuals

Arthritis &Rheumatology, EarlyView.
Objective To identify autoantibodies in presymptomatic individuals that associate with the onset of rheumatoid arthritis (RA) and to distinguish early RA from osteoarthritis (OA), particularly in individuals lacking classic RA serologic markers. Methods We analyzed serum and plasma from three cohorts: presymptomatic individuals who later developed RA ...
Outi Sareila, Linda Johansson, Anders Lundquist, Monica Leu Agelii, Lei Cheng, Yibo He, Erik Lönnblom, Maria Andersson, Jan Kihlberg, Anders Esberg, Inger Gjertsson, Rikard Holmdahl, Solbritt Rantapää‐Dahlqvist   +12 more
wiley   +1 more source

Association of rs763780 variation in interleukin 17F gene with the risk of knee osteoarthritis

Fiyz̤, 2019
Background: The injuries in osteoarthritis are mediated by various cytokines, growth factors, and inflammatory factors and the importance of the interleukin 17 family in this disease is increasingly evident.
Hassan Hassani-Bafrani, Monavareh Ahmadi , Gholam Reza Khosravi, Erfan Khosravi , Mohammad Karimian   +4 more
doaj  

Computer assisted total knee arthroplasty using patient specific templates [PDF]

, 2006
Current techniques used for total knee arthroplasty (TKA) rely on conventional instrumentation (CI) systems that violate the intramedullary canals. The accuracy of these systems is questionable, and set up and assembly of their numerous pieces is time ...
Hefez, Mahmoud Alm El-din abdel, Hafez, Mahmoud Alm El-din Abdel   +1 more
core  

Optimization of Arthroscopic All‐Inside Meniscus Repair With a Probe

Arthroscopy Techniques, EarlyView.
Abstract Meniscal preservation is essential for knee function and long‐term joint health. All‐inside meniscus repair achieves outcomes comparable to the inside‐out technique, but technical challenges remain, including limited working space, suture cut‐out in degenerative tissue, unfavorable suture angles, and risk of cartilage injury or arthroscope ...
Hui‐Shan Angela Lim, Sir‐Young James Loh   +1 more
wiley   +1 more source

Surgical Technique for Treating Focal Osteochondral Knee Lesions Using an Aragonite‐Based Biphasic Scaffold

Arthroscopy Techniques, EarlyView.
Abstract Osteochondral lesions of the knee, particularly in patients with early osteoarthritic changes, remain a clinical challenge. The Agili‐C implant (CartiHeal, Smith & Nephew), an aragonite‐based osteochondral scaffold, offers a single‐stage, off‐the‐shelf solution designed to regenerate both cartilage and subchondral bone.
Eric Wang, Alexandra M. Cancio‐Bello, Katelyn T. Koschmeder, Bryn Berens, Anikar Chhabra   +4 more
wiley   +1 more source

Single‐Stage Repair of Complex Anterolateral Radial and Posterior Root Tears of the Lateral Meniscus, With a Concomitant Multiligament Knee Reconstruction of the Anterior Cruciate Ligament, Medial Collateral Ligament, Posterior Oblique Ligament, and Anterolateral Ligament in a Young Athlete

Arthroscopy Techniques, EarlyView.
Abstract Early meniscal repair and anatomic reconstruction in a multiligament knee injury optimizes outcomes and restores tibiofemoral mechanics. This technique describes a lateral meniscus posterior root and radial tear repair, with concomitant medial ramp repair, performed during single‐stage reconstruction of the anterior cruciate ligament ...
Romir Patel, Sarah L. Larson, Benjiman J. Wilebski, Luke V. Tollefson, Matthew T. Rasmussen, Dustin R. Lee, Robert F. LaPrade   +6 more
wiley   +1 more source