Results 141 to 150 of about 437,057 (299)

Global Variability in Discoid Meniscus Management: A Comparative Study of Pediatric Research in Sports Medicine Asia‐Pacific and the Surgical Cohort Outcome Registry Experience Registry

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To compare diagnostic emphasis and surgical management strategies for discoid meniscus (DM) between Asia‐Pacific surgeons participating in the Pediatric Research in Sports Medicine collaborative and North American surgeons within the Surgical Cohort Outcome Registry Experience registry.
Si Jian Hui, Khim Yew Chew, Jacqueline Jin Li Liew, Ryan Wai Keong Loke, Henry Ellis, Qi‐Wei Lee, James Hoi Po Hui   +6 more
wiley   +1 more source

CD14 Plays a Critical Role in Pain and Inflammation Across Multiple Models of Post‐traumatic Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine osteoarthritis (OA) models that vary in severity of pathology and rate of progression to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt, Sanique M. South, Natalie S. Adamczyk, Vu Nguyen, Shingo Ishihara, Cheng Zhou, Kate L. Sharp, Sung Y. Kim, Anna E. Rapp, Baofeng Hu, Lance A. Murphy, Li‐Yin Hung, De'Broski Herbert, Joshua F. Baker, Robert L. Mauck, Timothy M. Griffin, Anne‐Marie Malfait, Rachel E. Miller, Carla R. Scanzello   +18 more
wiley   +1 more source

Behavioral Incentives for Exercise and Intra‐Articular Glucocorticoids for Knee Osteoarthritis: Results From a Factorially Designed Pragmatic Randomized Clinical Trial

Arthritis &Rheumatology, EarlyView.
Objective The purpose of this study was to determine the benefit of a behaviorally designed incentive program and glucocorticoid injections in reducing symptoms and promoting physical activity in patients with knee osteoarthritis (KOA). Methods This was a pragmatic, multisite, factorially designed, blinded, randomized clinical trial.
Joshua F. Baker, Katherine D. Wysham, Mercedes Quinones, Bryant R. England, Kaitian Jin, Marianna Olave, Sarah Wetzel, Rachel L. Gillcrist, Criswell Lavery, Natalie Keller, Bridget Kramer, Bibianna Ateh, Hannah Brubeck, Daniel K. White, Alexis Ogdie, Rui Xiao, Tuhina Neogi, Carla R. Scanzello   +17 more
wiley   +1 more source

Autoantibodies to Joint‐Related Peptides Are Associated With Onset of Rheumatoid Arthritis in Presymptomatic Seronegative Individuals

Arthritis &Rheumatology, EarlyView.
Objective To identify autoantibodies in presymptomatic individuals that associate with the onset of rheumatoid arthritis (RA) and to distinguish early RA from osteoarthritis (OA), particularly in individuals lacking classic RA serologic markers. Methods We analyzed serum and plasma from three cohorts: presymptomatic individuals who later developed RA ...
Outi Sareila, Linda Johansson, Anders Lundquist, Monica Leu Agelii, Lei Cheng, Yibo He, Erik Lönnblom, Maria Andersson, Jan Kihlberg, Anders Esberg, Inger Gjertsson, Rikard Holmdahl, Solbritt Rantapää‐Dahlqvist   +12 more
wiley   +1 more source

Genetic and Population Analyses Implicate Thyroid‐Related Regulation of RNF144B in Chondrocalcinosis

Arthritis &Rheumatology, EarlyView.
Objective Chondrocalcinosis, characterized by calcium crystal deposition within articular cartilage, affects 5% to 15% of the general population and has recently been identified as an osteoarthritis risk factor. However, its biologic pathways remain unclear.
Yahong Wu, Yanning Xu, Paul C. Okoro, Sirine Saafi, Jard de Vries, Xiaoyi Qi, Edwin H. G. Oei, Sita Bierma‐Zeinstra, Trudy Voortman, David Felson, Joyce B. J. van Meurs, Layal Chaker, J. Mark Wilkinson, Michelle S. Yau, Jessica Bertrand, Cindy G. Boer   +15 more
wiley   +1 more source

Early Synovial Regulatory T Cell Engagement in Posttraumatic Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Posttraumatic osteoarthritis (PTOA) develops despite restoration of joint biomechanics, suggesting that early postinjury biologic processes within the synovium shape disease trajectories. We investigated whether synovial Treg cells are engaged during the early phase following joint injury and whether experimental enrichment of this ...
Xueyou Zhang, Mingde Cao, Jianting Li, Bruma Sai‐Chuen Fu, Michael Tim‐Yun Ong, Patrick Shu‐Hang Yung   +5 more
wiley   +1 more source

Association of rs763780 variation in interleukin 17F gene with the risk of knee osteoarthritis

Fiyz̤, 2019
Background: The injuries in osteoarthritis are mediated by various cytokines, growth factors, and inflammatory factors and the importance of the interleukin 17 family in this disease is increasingly evident.
Hassan Hassani-Bafrani, Monavareh Ahmadi , Gholam Reza Khosravi, Erfan Khosravi , Mohammad Karimian   +4 more
doaj  

Optimizing Efficacy to Safety Ratio of Glucocorticoids in Rheumatoid Arthritis Models by Leveraging Peroxisome Proliferator–Activated Nuclear Receptor‐α Agonism

Arthritis &Rheumatology, EarlyView.
Objective Glucocorticoids remain essential therapies for immune and inflammatory diseases such as rheumatoid arthritis (RA) but are notorious for their metabolic side effects. Given the anti‐inflammatory and metabolically favorable actions of peroxisome proliferator–activated nuclear receptor (PPAR) agonists, we investigated whether PPARα agonism could
Lisa L. Koorneef, Elisabeth Gilis, Dorien Clarisse, Daria Fijalkowska, Sara Dufour, Julie Coudeneys, Bert Luyckx, Annick Verhee, Jonathan Thommis, Candice Vanden Bussche, Ulf Müller‐Ladner, Elena Neumann, Matthias Kerkhofs, Guillaume Planckaert, Simon Devos, Leander Meuris, Dirk Elewaut, Karolien De Bosscher   +17 more
wiley   +1 more source

Transcriptomic Profiling in Skeletal Muscle Identifies Associations With Knee Osteoarthritis: The Study of Muscle, Mobility and Aging

Arthritis &Rheumatology, EarlyView.
Objective The association between skeletal muscle gene expression and knee osteoarthritis (OA) was examined among older adult participants of the Study of Muscle, Mobility and Aging (SOMMA). Methods Inclusion criteria included knee radiographs and bulk RNA sequencing in vastus lateralis muscle, resulting in 523 participants (56% female).
Daniel S. Evans, Tyler A. Mansfield, Gina M. Many, Tyler J. Sagendorf, Samaneh Farsijani, Bret H. Goodpaster, Lauren M. Sparks, Nancy E. Lane   +7 more
wiley   +1 more source

MDL‐800–Induced Sirtuin 6 Activation Decreases Age‐Associated Osteoarthritis in Mice

Arthritis &Rheumatology, EarlyView.
Objective Sirtuin 6 (SIRT6) is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of MDL‐800, a small molecule activator of SIRT6, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source