Results 121 to 130 of about 146,043 (313)
Advanced Science, EarlyView.NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao +8 more
wiley +1 more source
Standardising the clinical assessment of coronal knee laxity [PDF]
, 2012 Clinical laxity tests are used for assessing knee ligament injuries and for soft tissue balancing in total knee arthroplasty. This study reports the development and validation of a quantitative technique of assessing collateral knee laxity through ...
Riches, Philip E. +5 more
core +1 more source
Advanced Science, EarlyView.Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu +7 more
wiley +1 more source
Effects of Severity of Degeneration on Gait Patterns in Patients with Medial Knee Osteoarthritis [PDF]
, 2009 This study tested the hypothesis that patients with mild and severe medial knee osteoarthritis (OA) adopt different compensatory gait patterns to unload the deseased knee, in not only the frontal plane but also the sagittal plane.
黃世傑;王廷明;劉彥宏;陳顥齡;呂東武;林昭庚 +1 more
core +1 more source
Advanced Science, EarlyView.We have shown that both simulated and actual spaceflight contribute to cartilage degradation in the knees of mice. Using RNA sequencing and bioenergetic profiling, we identified NADPH oxidase 4 (NOX4) as a key factor driving these changes. Additionally, we found that kaempferol, a naturally occurring flavonoid that binds directly to NOX4, reduces ...
Yuesong Yin +23 more
wiley +1 more source
Radiographic assessment of knee-ankle alignment after total knee arthroplasty for varus and valgus knee osteoarthritis [PDF]
, 2017 Background: There are unanswered questions about knee-ankle alignment after total knee arthroplasty (TKA) for varus and valgus osteoarthritis (OA) of the knee. The aim of this retrospective study was to assess knee-ankle alignment after TKA.
Sun, Wei +5 more
core +1 more source
Advanced Science, EarlyView.In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang +19 more
wiley +1 more source
Advanced Science, EarlyView.In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma +10 more
wiley +1 more source
The efficacy of two-drug regimen of glucosamine and chloroquine compared to one-drug regimen of glucosamine in treatment of knee osteoarthritis [PDF]
Objective: This study aimed to compare the clinical efficacy of two-drug regimen of glucosamine and chloroquine with one-drug regimen of glucosamine in treatment of knee osteoarthritis.
محرم زاد, یاشار +2 more
core
American Journal of Industrial Medicine, EarlyView.ABSTRACT Background Homecare aides (HCAs) are professional non‐family caregivers, who support dependent individuals to live at home with dignity; yet in Spain they remain understudied and vulnerable, often facing precarious working conditions. We aimed to characterize HCAs’ employment, living conditions, health, and exposure to workplace violence and ...
Albert Navarro‐Giné +6 more
wiley +1 more source