Results 101 to 110 of about 416,194 (299)

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Dynamic knee joint mechanics after anterior cruciate ligament reconstruction. [PDF]

, 2014
There is a scarcity of information on the long term adaptations in lower limb biomechanics during game specific movements after an anterior cruciate ligament (ACL) reconstruction.
Harrison, Andrew, Andrew J. Harrison, Sarah Breen (3923378), Kenny, Ian, Harrison, Andrew J., Kenny, IC, Ian C. Kenny (10230734), Ian C. Kenny, Sarah Clarke, Breen, Sarah, Clarke, Sarah B, Sarah Clarke (6337823), Kenny, Ian C., Andrew J. Harrison (7239119), Clarke, Sarah, Clarke, SB, Harrison, AJ   +16 more
core   +1 more source

Expert Consensus on the Management of Obesity in Older Adults (2026 Edition)

AGING MEDICINE, EarlyView.
This graphical abstract summarizes a safety‐first framework for managing obesity in older adults, with attention to age, functional status, comorbidities, and sarcopenia risk. Key assessments include BMI, waist measures, body fat percentage, skeletal muscle mass, and comprehensive geriatric evaluation. Management prioritizes reducing visceral fat while
Qi Pan, Lixin Guo
wiley   +1 more source

Do individuals with knee osteoarthritis walk with distinct knee biomechanics and muscle activation characteristics? An investigation of knee osteoarthritis, hip osteoarthritis, and asymptomatic groups.

, 2021
Knee osteoarthritis is a musculoskeletal condition affecting mobility and function. Hallmark biomechanical indicators have been linked knee OA severity and progression, yet it remains unknown whether these are exclusive to the OA knee.
Lohnes, Jessica
core  

Short-term efficacy of physical interventions in osteoarthritic knee pain. A systematic review and meta-analysis of randomised placebo-controlled trials [PDF]

, 2007
Background Treatment efficacy of physical agents in osteoarthritis of the knee (OAK) pain has been largely unknown, and this systematic review was aimed at assessing their short-term efficacies for pain relief.
Anne E Ljunggren, Roberta Chow, Chow, Robert, Jan M Bjordal, Lopes-Martins, Rodrigo A.B., Lopes-Martins, RA, Rodrigo AB Lopes-Martins, Bjordal, Jan M, Bogen, B, Johnson Mark I, Ljunggren, AE, Bjordal Jan M, Chow, Roberta , Ljunggren, Anne E, Bjordal, JM, Chow, Roberta, Bogen, Bård, Ljunggren Anne E, Chow, R, Johnson, Mark I., Lopes-Martins, Rodrigo Álvaro Brandão, Ljunggren, Anne Elisabeth, Bjordal, Jan Magnus, Lopes-Martins Rodrigo AB, Johnson, MI, Bogen Bård, Ljunggren, Anne E., Mark I Johnson, Bård Bogen, Lopes-Martins, Rodrigo AB, Johnson, Mark I, Chow Roberta, Bogen, Bård    +32 more
core   +2 more sources

Characterization and Analysis of PHEX Variants in Patients With Hypophosphatemia in Argentina

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Confirming the underlying molecular etiology of hereditary hypophosphatemia (HH) to provide recurrence risk counseling is highly important. Our aims were to describe the detected variants and their distribution across Argentina and to contrast them with published data.
Silvia Ávila, Sara Fernández, Maximiliano Zeballos, María Georgina Poggio   +3 more
wiley   +1 more source

Prevalence, functional impact, and associated factors of knee osteoarthritis and knee pain among adults in Urumqi, Northwest China: a community-based cross-sectional study

Frontiers in Public Health
BackgroundKnee osteoarthritis and knee pain are major causes of chronic pain, functional limitation, and health-care use, but community-level evidence on their symptomatic burden and associated factors remains limited in northwest China.
Lingyun Shi, Lingyun Shi, Siqi Li, Jiaju Zhao, Guoliang Hou, Abiding Abulaiti, Xiaomin Lin, Haitao Zhang, Palida Maimaiti   +8 more
doaj   +1 more source

The EXPLAIN Study: Exploring Arthrogryposis Multiplex Congenita in Adults in Norway — A Description of Demographic, Medical, and Neurological Findings

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis Multiplex Congenita (AMC) encompasses several hundred conditions with diverse genetic, pathophysiological, and clinical origins. The overarching EXPLAIN study explores underlying causes and implications of AMC and represents the largest clinical cohort of adults with AMC reported to date.
My Vuong Hermansen, Kristin Ørstavik, Unni Steen, Mathias Toft, Cathrine Brunborg, Lena Lande Wekre   +5 more
wiley   +1 more source

Notchplasty for the Arthroscopic Treatment of Limited Knee Extension

Arthroscopy Techniques, 2017
Knee osteoarthritis may lead to narrowing of the intercondylar notch due to osteophyte formation, thereby causing changes in native knee biomechanics.
Marcio B. Ferrari, M.D., Sandeep Mannava, M.D., Ph.D., Nicholas DePhillipo, M.S., A.T.C., George Sanchez, B.S., Robert F. LaPrade, M.D., Ph.D.   +4 more
doaj   +1 more source

Adipose‐derived mesenchymal stem cell injection into the KI10 acupoint mitigates cartilage damage in KOA rats through PGE2‐mediated α7nAChR/NF‐κB pathway

Animal Models and Experimental Medicine, EarlyView.
In our research, KOA rat models were established and treated with ADSC injection into the KI10 acupoint. Pain relief, behavioral function, and joint structural improvements were systematically assessed using ethological tests, imaging, histopathological staining, transmission electron microscopy, and molecular analyses.
Mengwei Dong, Wenfang Li, Wanpeng Yang, Te Ba, Nan Nan, Yang Liu, Jing Han, Huiqin Hao   +7 more
wiley   +1 more source