Results 91 to 100 of about 146,043 (313)

Health beliefs before and after participation on an exercised-based rehabilitation programme for chronic knee pain: doing is believing [PDF]

, 2010
BACKGROUND: To explore the health beliefs, experiences, treatment and expectations of people with chronic knee pain, and investigate if, how and why these change after taking part on an integrated exercise-based rehabilitation programme--Enabling Self ...
Bhavnani, Vanita, Stevenson Fiona, Stevenson, Fiona, Fiona Stevenson, Hurley, Michael V., Bhavnani Vanita, Britten Nicky, Walsh, Nicola, Bhavnani, V, Vanita Bhavnani, Walsh, N, Britten, N, Hurley, MV, Nicky Britten, Stevenson, F, Hurley Michael V, Britten, Nicky, Walsh Nicola, Hurley, Michael V, Nicola Walsh, Michael V Hurley   +20 more
core   +1 more source

Lower Income and Nonheterosexual Orientation Are Associated With Poor Access to Care in Patients With Knee Osteoarthritis

Arthroplasty Today
Background: Social determinants of health are implicated in the experience of knee osteoarthritis, a key component of which is access to care and healthcare utilization.
Sayi P. Boddu, BA, Vikram S. Gill, BS, Jack M. Haglin, MD, Joseph C. Brinkman, MD, David G. Deckey, MD, Joshua S. Bingham, MD   +5 more
doaj   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

The Warwick patellofemoral arthroplasty trial : a randomised clinical trial of total knee arthroplasty versus patellofemoral arthroplasty in patients with severe arthritis of the patellofemoral joint [PDF]

, 2011
Background Severe arthritis of the knee is a disabling condition, with over 50,000 knee replacements performed each year in the UK. Isolated patellofemoral joint arthritis occurs in over 10% of these patients with the treatment options being ...
Costa, Matthew L., Tim Spalding, Parsons, Nicholas R., Spalding, Tim, Achten, Juul, McGuinness, Katie, Nick Parsons, Parsons Nick, Spalding Tim, Matthew Costa, Achten Juul, Michelle Odumenya, McGuinness Katie, Odumenya, M. (Michelle), Katie McGuinness, Odumenya Michelle, Costa Matthew, Juul Achten   +17 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Knee osteoarthritis and obesity

International Journal of Obesity, 2001
To assess the risk of knee osteoarthritis (OA) attributable to obesity, and the interactions between obesity and other established causes of the disorder.We performed a population-based case-control study in three health districts of England (Southampton, Portsmouth and North Staffordshire).
Coggon, D., Reading, I., Croft, P., McLaren, M., Barrett, D.S., Cooper, C.   +5 more
openaire   +4 more sources

An Implantable Optogenetics‐Engineered Hydrogel for Amelioration of Rheumatoid Arthritis through Light‐Controlled Metabolic Reprogramming of Synovial Macrophages

Advanced Science, EarlyView.
An implantable hydrogel is designed to enable in situ and on‐demand secretion of GLP‐1 in synovium through blue light irradiation to activate GLP‐1R/HK2/VDAC1 pathway for upregulating tricarboxylic acid cycle and oxidative phosphorylation in macrophage, facilitating tissue repair and bone erosion recovery.
Dahai Hu, Yaru Sun, Qi Lu, Yi Zhang, Jieruo Li, Huige Hou, Huajun Wang, Hui Tang, Yunsong Zhang, Xiaofei Zheng, Qingsong Mei   +10 more
wiley   +1 more source

Revision rates after primary hip and knee replacement in England between 2003 and 2006 [PDF]

, 2008
<b>Background</b>: Hip and knee replacement are some of the most frequently performed surgical procedures in the world. Resurfacing of the hip and unicondylar knee replacement are increasingly being used.
Boroff, Mick, Pickford, M., Borroff, Mick, Keith Tucker, Tucker, K., MacGregor, Alex J., on behalf of the Steering Committee of the National Joint Regist, Macgregor, AJ, Copley, LP, Lynn P Copley, Lewsey, J.D., Pickford, M, Copley Lynn P, Lewsey, Jim D., Tucker, K, Copley, Lynn P, Borroff, M, Lewsey, JD, Gregg, Paul, Gregg, P, Pickford Martin, van der Meulen, JH, Porter, Martyn, Sibanda, N, Lewsey Jim D, Copley, L.P., Mick Borroff, Paul Gregg, Porter, M, Copley, Lynn P., Porter Martyn, Martyn Porter, Jan H van der Meulen, Sibanda Nokuthaba, Gregg Paul, MacGregor, A.J., Alex J MacGregor, Borroff Mick, van der Meulen, J.H., Steering Committee of the National Joint Registry (NJR) for England and Wales, Sibanda, Nokuthaba, MacGregor, Alex J, Tucker Keith, Pickford, Martin, Tucker, Keith, Nokuthaba Sibanda, Sibanda, N., van der Meulen, Jan H, Steering Committee of the National Joint Registry (NJR) for Engl, MacGregor Alex J, Porter, M., Gregg, P., van der Meulen, Jan H., Borroff, M., Martin Pickford, van der Meulen Jan H, Lewsey, Jim D, Jim D Lewsey   +57 more
core   +1 more source

Factors associated with knee pain in 5148 women aged 50 years and older: A population-based study.

PLoS ONE, 2018
ObjectiveThis study was performed to investigate the factors associated with the level of knee pain in a nationally representative sample of noninstitutionalized women aged 50 years or older.MethodsWomen aged 50 years or older were selected and included ...
Kyoung Min Lee, Seung-Baik Kang, Chin Youb Chung, Moon Seok Park, Dong-Wan Kang, Chong Bum Chang   +5 more
doaj   +1 more source

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source