Results 81 to 90 of about 437,057 (299)

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

Effect of Romosozumab Treatment in Postmenopausal Women With Osteoporosis and Knee Osteoarthritis: Results From a Substudy of a Phase 3 Clinical Trial

ACR Open Rheumatology
Objective Romosozumab is a bone‐forming agent approved for osteoporosis treatment. Here we report results of the protocol‐specified, noninferiority osteoarthritis substudy of the fracture study in postmenopausal women with osteoporosis (FRAME), which ...
Nancy E. Lane, Donald Betah, Cynthia Deignan, Mary Oates, Zhenxun Wang, Jen Timoshanko, Aliya A. Khan, Neil Binkley   +7 more
doaj   +1 more source

Numerical analysis of cartilage surfaces for osteoarthritis diagnosis using field and feature parameters [PDF]

, 2011
Osteoarthritis (OA) is one of the most common degenerative wear diseases of knee joints worldwide. Within knee joint articular cartilage (AC), collagen structure losing integrity is a major symptom of OA.
Jiang, X., Wang, Jian, Tian, Y., Z. Peng, X. Jiang, J. Wang, Jiang, Xiang, Y. Tian, Wang, J., Peng, Z.   +9 more
core   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
openaire   +2 more sources

Metabolic‐Redox Remodeling of Inflammatory Synovium by Mannose‐Modified Selenium Nanoparticles for Osteoarthritis Therapy

Advanced Science, EarlyView.
Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Yu‐Qing Zou, Chen‐Hao Xu, Bo‐Wei Li, Leung Chan, Yi‐Di Xu, Han‐Bo Su, Rui Peng, Fang‐Ji Luo, Ya‐Chen Peng, Zhen‐Yan Li, Vincent Kam Wai Wong, Xiao‐Fei Zheng, Xing Ma, Zhen‐Gang Zha, Tianfeng Chen, Huan‐Tian Zhang   +15 more
wiley   +1 more source

Factors associated with knee pain in 5148 women aged 50 years and older: A population-based study.

PLoS ONE, 2018
ObjectiveThis study was performed to investigate the factors associated with the level of knee pain in a nationally representative sample of noninstitutionalized women aged 50 years or older.MethodsWomen aged 50 years or older were selected and included ...
Kyoung Min Lee, Seung-Baik Kang, Chin Youb Chung, Moon Seok Park, Dong-Wan Kang, Chong Bum Chang   +5 more
doaj   +1 more source

Do individuals with knee osteoarthritis walk with distinct knee biomechanics and muscle activation characteristics? An investigation of knee osteoarthritis, hip osteoarthritis, and asymptomatic groups.

, 2021
Knee osteoarthritis is a musculoskeletal condition affecting mobility and function. Hallmark biomechanical indicators have been linked knee OA severity and progression, yet it remains unknown whether these are exclusive to the OA knee.
Lohnes, Jessica
core  

The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a mendelian randomisation study [PDF]

, 2013
ObjectiveVariation in the fat mass and obesity-associated (FTO) gene influences susceptibility to obesity. A variant in the FTO gene has been implicated in genetic risk to osteoarthritis (OA).
Pannoutsopoulou, K., Wheeler, M., Jones, G., Spector, T.D., Laslett, L.L., Cicuttini, F.M., Cooper, C., Metrustry, S., Zhang, W., Doherty, S., Arden, N.K., Doherty, M., Valdes, A.M., Zeggini, E., Maciewicz, R.A., Hart, D.J., Muir, K.R., Arden, Nigel K, HASH(0x55a67fff9a48), Cicuttini, Flavia M; id_orcid, Valdes, Ana Maria, Zeggini, Eleftheria, Valdes, Ana M., Laslett, Laura L, Doherty, Sally A., Muir, Kenneth R., Zhang, Weiya, Arden, N., Jones, Graeme, ?, ?, Hart, Deborah J; id_orcid, Spector, T. D., Hart, Deborah J, Arden, Nigel K., Cicuttini, Flavia M., Valdes, Ana M, Muir, Kenneth, Hart, Deborah J., Doherty, Sally A, Cooper, Cyrus, Laslett, Laura L., Metrustry, Sarah, Maciewicz, Rose A., Maciewicz, Rose A, Cicuttini, Flavia M, Spector, Tim D., Wheeler, Margaret, Panoutsopoulou, Kalliope, Laslett, Laura, Muir, Kenneth R, Spector, Tim D, Doherty, Michael   +51 more
core   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

A Multi‐Structural Radiomic Digital Phenotyping Framework for Deciphering Preclinical Evolution of Degenerative Meniscal Tears

Advanced Science, EarlyView.
Subclinical matrix disruption precedes degenerative meniscal tears across the knee joint. A spatial compartmental radiomics model utilizing 3D‐DESS MRI captures early osteochondral destabilization, accurately predicting incident tears up to four years pre‐collapse. Feature attributions uncover coordinated chondral and osseous alterations, advancing non‐
Shengfa Li, Hao Liu, Yanbin Zhu, Hang Zhang, Qifeng Tao, Wenbo Zhao, Xin Miao, Shanshan Yang, Tianyu Chen, David Hunter, Changhai Ding, Ting Wang, Juan Wang, Wei Chen   +13 more
wiley   +1 more source