Results 121 to 130 of about 334,556 (277)

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

Med Research, EarlyView.
This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei, Xiaoxian Lou, Xu Su, Shubao Liu, Yanli Tong, Jie Chen, Xuerui Chen, Wenjun Mao, Hui Yu, Liangbin Lin   +9 more
wiley   +1 more source

Clinical Outcomes of Kinematic Alignment Versus Mechanical Alignment in Total Knee Arthroplasty: An Umbrella Review of Published Meta‐Analyses and Systematic Reviews

Medicine Advances, EarlyView.
This is the first umbrella review that collates the evidence from 11 meta‐analyses (30 studies, 2963 patients) to conduct the highest‐level comparison between kinematic alignment (KA) and mechanical alignment (MA) in total knee arthroplasty (TKA).
Chuanxin Wang, Haisheng Yu, Bingyang Yan, Dezhi Yan, Wenfei Wu, Di Luo, Yanbo Guo, Wenzhao Wang, Liang Ma   +8 more
wiley   +1 more source

SURMOUNT‐REAL UK: A Pragmatic Randomized Clinical Trial to Assess the Effectiveness of Tirzepatide in Adults With Obesity

Obesity, EarlyView.
ABSTRACT Objective SURMOUNT‐REAL UK will evaluate the effectiveness of tirzepatide when offered in addition to standard‐of‐care (SoC) in adults with Class I obesity (BMI ≥ 30 and ≤ 34.9 kg/m2) and without diabetes in a UK primary care setting. Methods A 5‐year, phase 4, multicenter, open‐label, pragmatic randomized clinical trial is enabled through ...
Martin K. Rutter, Julie Mount, J. Martin Gibson, Joanne Webb, Cheryl Marler, Catherine Reed, Mugdha Gore, Wenyu Ye, Elisa Gomez Valderas, John Wilding, Naveed Sattar, Melanie J. Davies, Kamlesh Khunti, Richard Haynes, Rachel L. Batterham   +14 more
wiley   +1 more source

Knee prosthesis

, 2013
HOWARD MICHAEL J, JOHANNABER KENNETH D
  +7 more sources

Design, Analysis, and Development of Low-Cost State-of-the-Art Magnetorheological-Based Microprocessor Prosthetic Knee

Sensors
For amputees, amputation is a devastating experience. Transfemoral amputees require an artificial lower limb prosthesis as a replacement for regaining their gait functions after amputation.
Muhammad Usman Qadir, Izhar Ul Haq, Muhammad Awais Khan, Kamran Shah, Houssam Chouikhi, Mohamed A. Ismail   +5 more
doaj   +1 more source

Longitudinal improvements in comfort, mobility, and quality of life with adjustable‐volume prosthetic sockets

PM&R, EarlyView.
Abstract Background The prosthetic socket is central to the comfort, function, and satisfaction for lower‐limb prosthesis users. Traditional fixed‐geometry sockets offer limited adjustability and sometimes fail to accommodate daily changes in residual limb volume or shape, leading to poor load distribution, discomfort, skin issues, and reduced quality ...
Dwiesha L. England, Phillip M. Stevens, Aolani M. Wheeler, Bretta L. Fylstra, Kathleen M. Carroll, Emily A. Steffensen, Todd J. Castleberry, Shane R. Wurdeman   +7 more
wiley   +1 more source

Gait Analysis of Patients with a Rotating Hinge Knee Prosthesis after Revision Total Knee Arthroplasty [PDF]

Background: The number of revision total knee arthroplasty (TKA) procedures performed worldwide is increasing. The rotating hinge knee type (RHK) prosthesis is used for revision TKA.
Misaki, Sadaya, 島村, 亮太, ヤマダ, タクミ, Yamada, Takumi, Shimamura, Ryota, 杉本, 和隆, Tazawa, Tomohiro, タザワ, トモヒロ, 山田, 拓実, Ohmi, Takehiro, ミサキ, サダヤ, 大見, 武弘, シマムラ, リョウタ, スギモト, カズタカ, カトウ, ジュンペイ, Sugimoto, Kazutaka, 美﨑, 定也, 加藤, 淳平, Kato, Junpei, オオミ, タケヒロ, 田澤, 智央   +20 more
core   +1 more source

Effects of adjustable‐volume transfemoral prosthetic sockets on balance and falls: A randomized clinical trial

PM&R, EarlyView.
Abstract Background Adjustable‐volume prosthetic sockets have been developed to allow users to accommodate volume fluctuations throughout the day. Improvement in socket fit is thought to enhance the connection between the user's residual limb and prosthesis and may therefore improve postural control and balance.
Deanna H. Gates, Jeffrey Wensman, Anthony R. Gutierrez, Jordan Kartes, Marco A. Avalos, Jenevieve A.W. Surkin, Noah J. Rosenblatt   +6 more
wiley   +1 more source

Risk of septic arthritis following corticosteroid and platelet‐rich plasma injections: A multicenter retrospective review

PM&R, EarlyView.
Abstract Background Platelet‐rich plasma injections (PRPI) are a relatively new and evolving treatment option for a variety of musculoskeletal injuries. It has been theorized that there is an increased risk of septic arthritis (SA) with PRPI, though there have been no dedicated studies to assess the incidence of SA and only three cases have been ...
Kory Ford, James Frazier, Anthony Beutler, Catherine Fairgrieve Appel, Daniel M. Cushman   +4 more
wiley   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source