Results 131 to 140 of about 131,943 (315)

Dynamic changes to the tibiofemoral joint line with increasing osteoarthritis severity and its relationship to constitutional alignment: a radiological analysis of 3,320 knees

Bone & Joint Open
Aims: Changes in both native and dynamic joint line obliquity may influence the pathogenesis of osteoarthritis (OA) and subsequent development of coronal limb alignment deformity.
John E. Farey, Benjamin J. Leong, Jil A. Wood, Do W. Lee, Seyun Kim, Darren B. Chen, Du H. Ro, Samuel J. MacDessi   +7 more
doaj   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

knees

, 1980
kneesI prepared a keel, c ut a couple of knees to make timbers, and I also got some plank sawed.GMS Nov 80Used IUsed IWithdrawnknee-cap boot, knee-knocked, knee knockers, knee-slideChecked by Raji Sreeni on Wed 12 Aug 2015; What looks like an 'e' has ...

core  

Long-term outcomes of the cementless Oxford Unicompartmental Knee Replacement: a 16-year follow-up study

Bone & Joint Open
Aims: Cementless fixation is an alternative to cemented unicompartmental knee arthroplasty (UKA), with several advantages over cementation. This study reports on the 16-year survival and ten-year clinical and radiological outcomes of the cementless ...
Jessica Mowbray, Owain Lloyd Ioan Davies, Christopher Frampton, Alistair Rodney Maxwell, Gary John Hooper   +4 more
doaj   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

Ultrasonographic Findings in Hemiplegic Knees of Stroke Patients

, 2005
Clinical and radiologic asymmetric arthritic differences between paralyzed and nonparalyzed limbs of stroke patients have been reported. Arthritic pathology aggravates motor dysfunction and compromises rehabilitation.
Weng, Ming-Cheng, Tien-Wen Chen, Lee, Chia-Ling, Lee, Su, Chia-Ling Lee, Yang, Chao-Pin, Mao-Hsiung Huang, Huang, Mao-Hsiung, Su Lee, Chao-Pin Yang, Chen, Tien-Wen, Ming-Cheng Weng   +11 more
core   +1 more source

Automated deep-learning quantification of nine patellofemoral instability parameters on multislice CT images: development and validation of the GU2Net model

Bone & Joint Open
Aims: Objective and precise measurement of patellar instability (PI) parameters on CT images is essential for accurate diagnosis and treatment planning. However, manual assessment is tedious, time-consuming, and prone to error.
Qin Ye, Yingying Ying, Jiake Hua, Junfen Ye, Chengxin Zhu, Bowen Zheng   +5 more
doaj   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

First knee for pain and function versus second knee for quality of life: a registry study of patient-reported outcomes following staged bilateral knee arthroplasty in Australia

Bone & Joint Open
Aims: The aim of this study was to describe and compare joint-specific and generic health-related quality of life outcomes of the first versus second knee in patients undergoing staged bilateral total knee arthroplasty (BTKA) for osteoarthritis. Methods:
Adriane M. Lewin, Kara Cashman, Dylan Harries, Ilana N. Ackerman, Justine M. Naylor, Ian A. Harris   +5 more
doaj   +1 more source