Results 11 to 20 of about 2,218 (164)
International Journal of Imaging Systems and Technology, 2023 AbstractMultiple myeloma disrupts normal blood cell production, requiring early detection due to the increased risk of bone metastases. Although various artificial intelligence (AI) methods have been developed to assist pathologists, they often lack comprehensive metrics to measure both detection and segmentation errors.
Salvi, Massimo +7 more
openaire +3 more sources
The area under the effect curve as an efficacy determinant for anti-infectives. [PDF]
CPT Pharmacometrics Syst Pharmacol, 2022 Abstract Pharmacokinetic/pharmacodynamic (PK/PD) indices making use of area under the curve, maximum concentration, and the duration that in vivo drug concentration is maintained above a critical level are commonly applied to clinical dose prediction from animal efficacy experiments in the infectious disease arena.
Chen C, Lavezzi SM, Iavarone L.
europepmc +2 more sources
Sodium MRI of the Lumbar Intervertebral Discs of the Human Spine: An Ex Vivo Study. [PDF]
J Magn Reson ImagingBackground Lower back pain affects 75%–85% of people at some point in their lives. The detection of biochemical changes with sodium (23Na) MRI has potential to enable an earlier and more accurate diagnosis. Purpose To measure 23Na relaxation times and apparent tissue sodium concentration (aTSC) in ex‐vivo intervertebral discs (IVDs), and to investigate
Kamp B +11 more
europepmc +2 more sources
Scrambled eggs—Negative impacts of heat stress and chemical exposures on ovarian function in swine
Molecular Reproduction and Development, Volume 90, Issue 7, Page 503-516, July 2023., 2023 Abstract Exposure to environmental toxicants and hyperthermia can hamper reproduction in female mammals including swine. Phenotypic manifestations include poor quality oocytes, endocrine disruption, infertility, lengthened time to conceive, pregnancy loss, and embryonic defects.
M. Estefanía González‐Alvarez +2 more
wiley +1 more source
Chemistry – A European Journal, Volume 29, Issue 33, June 13, 2023., 2023 The ligase chain reaction lesion‐induced DNA amplification exhibits rapid self‐replication avoiding the product inhibition problem of most nucleic acid systems. We find the abasic lesion destabilizes the product duplex more than the intermediate complex narrowing their stability gap. The selective stabilization of the intermediate complex by the enzyme
Hansol Park +4 more
wiley +1 more source
Ripley’s K‐function for Network‐Constrained Flow Data
Geographical Analysis, Volume 54, Issue 4, Page 769-788, October 2022., 2022 Many types of spatial flows, including pedestrian flows and vehicle flows, are constrained by and distribute on spatial networks. In the literature, network‐constrained flows are usually modeled as a direct line in planar space using methods designed for flows in planar space. Further, in spatial statistical analysis of flow patterns, distance measures
Zihan Kan, Mei‐Po Kwan, Luliang Tang
wiley +1 more source
Using partition analysis as a facile method to derive net clearances
Clinical and Translational Science, Volume 15, Issue 8, Page 1867-1879, August 2022., 2022 Abstract Partition analysis has been described previously by W.W. Cleland to derive net rate constants and simplify the derivation of enzyme kinetic equations. Here, we show that partition analysis can be used to derive elimination and transfer (distribution) net clearances for use in pharmacokinetic models.
Ken Korzekwa, Jaydeep Yadav, Swati Nagar
wiley +1 more source
British Journal of Pharmacology, Volume 179, Issue 6, Page 1251-1263, March 2022., 2022 Background and Purpose Translational efforts in the evaluation of novel anti‐tubercular drugs demand better integration of pharmacokinetic–pharmacodynamic data arising from preclinical protocols. However, parametric approaches that discriminate drug effect from the underlying bacterial growth dynamics have not been fully explored, making it difficult ...
Morris Muliaditan, Oscar Della Pasqua
wiley +1 more source
Research Overview on Edge Detection Algorithms Based on Deep Learning and Image Fusion
Security and Communication Networks, Volume 2022, Issue 1, 2022., 2022 Edge detection is a boundary‐based segmentation method to extract important information from an image, and it is a research hotspot in the fields of computer vision and image analysis. Especially feature extraction is also the basis of image segmentation, target detection, and recognition.
Bin Tian, Wei Wei, Yuchuan Luo
wiley +1 more source
SANTA: quantifying the functional content of molecular networks. [PDF]
PLoS Comput Biol, 2014 Linking networks of molecular interactions to cellular functions and phenotypes is a key goal in systems biology. Here, we adapt concepts of spatial statistics to assess the functional content of molecular networks.
Cornish AJ, Markowetz F.
europepmc +7 more sources