Results 141 to 150 of about 2,562 (158)

Bispecific Antibody and Antibody-Drug Conjugate as Novel Candidates for Treating Pancreatic Ductal Adenocarcinoma. [PDF]

Biomolecules
Seo H, Go D, Jung SY, Han S, Nguyen VQ, Kwak M, Um W.   +6 more
europepmc   +1 more source

Technological advancements in antibody-based therapeutics for treatment of diseases. [PDF]

J Biomed Sci
Lu RM, Chiang HL, Yuan JP, Wang HH, Chen CY, Panda SS, Liang KH, Peng HP, Ko SH, Hsu HJ, Kumari M, Su YJ, Tse YT, Chou NL, Wu HC.   +14 more
europepmc   +1 more source

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Extended knobs-into-holes packing in classical and complex coiled-coil assemblies☆

Journal of Structural Biology, 2003
This year marks the 50th anniversary of Crick's seminal paper on the packing of alpha-helices into coiled-coil structures. The central tenet of Crick's work is the interdigitation of side chains, which directs the helix-helix interactions; so called knobs-into-holes packing.
John Walshaw, Derek N Woolfson
exaly   +4 more sources

Proposed Knobs-Into-Holes Packing for Several Membrane Proteins

Membrane Biochemistry, 1978
We investigated the possible side chain/side chain interactions of four potential transmembrane proteins. The basic assumptions are that the proteins are alpha-helical, and that the proteins aggregate with knobs-into-holes packing. It was found that these four proteins can be assembled into stereochemically feasible bundles of alpha-helices with ...
A Keith Dunker
exaly   +3 more sources

Interaction of transmembrane helices by a knobs-into-holes packing characteristic of soluble coiled coils

Proteins: Structure, Function, and Genetics, 1998
Membrane-embedded protein domains frequently exist as alpha-helical bundles, as exemplified by photosynthetic reaction centers, bacteriorhodopsin, and cytochrome C oxidase. The sidechain packing between their transmembrane helices was investigated by a nearest-neighbor analysis which identified sets of interfacial residues for each analyzed helix-helix
Dieter Langosch, Jaap Heringa
exaly   +3 more sources

‘Knobs-into-holes’ provides a rational design strategy for engineering antibody CH3 domains for heavy chain heterodimerization

Immunotechnology: an International Journal of Immunological Engineering, 1996
P. Carter, J.B.B. Ridgway, L.G. Presta
exaly   +2 more sources

Probing the Impact of the Knob-into-Hole Mutations on the Structure and Function of a Therapeutic Antibody

Analytical Chemistry, 2019
Bispecific antibodies (BsAbs) have drawn increasing interest in the biopharmaceutical industry due to their advantage to bind two distinct antigens simultaneously. The knob-into-hole approach is an effective way to produce bispecific antibodies by driving heterodimerization with mutations in the CH3 domain of each half antibody.
Peilu Liu, Xuan Gao, Victor Lundin, Catherine Shi, Yilma Adem, Kevin Lin, Guoying Jiang, Yung-Hsiang Kao, Feng Yang, David Michels, Alan G. Marshall, Hui-Min Zhang   +11 more
openaire   +2 more sources

Rapid Identification of Disulfide Bonds and Cysteine-Related Variants in an IgG1 Knob-into-Hole Bispecific Antibody Enhanced by Machine Learning

Analytical Chemistry, 2018
Bispecific antibodies are regarded as the next generation of therapeutic modalities as they can simultaneously bind multiple targets, increasing the efficacy of treatments for several diseases and opening up previously unattainable treatment designs. Linking two half antibodies to form the knob-into-hole bispecific antibody requires an additional in ...
Jordan J. Baker, Dana McDaniel, David Cain, Paula Lee Tao, Charlene Li, Yuting Huang, Hongbin Liu, Judith Zhu-Shimoni, Milady Niñonuevo   +8 more
openaire   +2 more sources

Knobs-into-Holes Packing of α-helices: Coiled Coils and Beyond

Biochemical Society Transactions, 2000
J. Walshaw, D. N. Woolfson
openaire   +1 more source

Solvable models of quantum black holes: a review on Jackiw–Teitelboim gravity

Living Reviews in Relativity, 2023
Thomas Mertens, Gustavo Joaquin Turiaci
exaly