Results 11 to 20 of about 218,644 (293)

circ_AKT3 knockdown suppresses cisplatin resistance in gastric cancer

Open Medicine, 2022
Circular RNAs (circRNAs) are associated with cisplatin resistance in gastric cancer (GC). This study aims to explore the role of circRNA AKT serine/threonine kinase 3 (circ_AKT3) in the resistance of GC to cisplatin.
Shi Wenting, Wang Fang
doaj   +4 more sources

Knockdown resistance (kdr) mutations in Indian Anopheles culicifacies populations [PDF]

Parasites & Vectors, 2015
Background Anopheles culicifacies s.l. is one of the primary vectors of malaria in India responsible for the highest number of malaria cases. This vector is resistant to DDT in most parts of the country with indication of emerging resistance to ...
Cherry L. Dykes, Raja Babu S. Kushwah, Manoj K. Das, Shri N. Sharma, Rajendra M. Bhatt, Vijay Veer, Om P. Agrawal, Tridibes Adak, Om P. Singh   +8 more
doaj   +3 more sources

Absence of knockdown resistance suggests metabolic resistance in the main malaria vectors of the Mekong region [PDF]

Malaria Journal, 2009
Background As insecticide resistance may jeopardize the successful malaria control programmes in the Mekong region, a large investigation was previously conducted in the Mekong countries to assess the susceptibility of the main malaria vectors against ...
Tho Sochantha, Marc Coosemans, Coosemans Marc, Verhaeghen, Katrijn, Sochantha, Tho, Coosemans, Marc, van Bortel, Wim, Van Bortel Wim, Ho Trung, Katrijn Verhaeghen, Sochantha Tho, Wim Van Bortel, Verhaeghen Katrijn, Trung Ho, Ho, Din Trung   +14 more
core   +5 more sources

Investigating knockdown resistance (kdr) mechanism against pyrethroids/DDT in the malaria vector Anopheles funestus across Africa [PDF]

BMC Genetics, 2017
Background Understanding the molecular basis of insecticide resistance is key to improve the surveillance and monitoring of malaria vector populations under control. In the major malaria vector Anopheles funestus, little is currently known about the role
Helen Irving, Charles S. Wondji
doaj   +2 more sources

Discovery of super-insecticide-resistant dengue mosquitoes in Asia: Threats of concomitant knockdown resistance mutations. [PDF]

Sci Adv, 2022
Aedes aegypti (Linnaeus, 1762) is the main mosquito vector for dengue and other arboviral infectious diseases. Control of this important vector highly relies on the use of insecticides, especially pyrethroids.
Kasai S, Itokawa K, Uemura N, Takaoka A, Furutani S, Maekawa Y, Kobayashi D, Imanishi-Kobayashi N, Amoa-Bosompem M, Murota K, Higa Y, Kawada H, Minakawa N, Cuong TC, Yen NT, Phong TV, Keo S, Kang K, Miura K, Ng LC, Teng HJ, Dadzie S, Subekti S, Mulyatno KC, Sawabe K, Tomita T, Komagata O.   +26 more
europepmc   +4 more sources

Development of antisense-mediated myostatin knockdown for the treatment of insulin resistance [PDF]

Scientific Reports, 2021
AbstractMyostatin is a negative regulator of muscle mass and its inhibition represents a promising strategy for the treatment of muscle disorders and type 2 diabetes. However, there is currently no clinically effective myostatin inhibitor, and therefore novel methods are required.
Wouter Eilers, Mark Cleasby, Keith Foster   +2 more
openaire   +4 more sources

Knockdown resistance of Anopheles sinensis in Henan province, China [PDF]

Malaria Journal, 2015
Vivax malaria was historically epidemic in Henan Province of China and Anopheles sinensis was the main vectors and poor farming communities bare the greatest burden of disease. Knockdown resistance in An. sinensis is one of the mechanisms of resistance against pyrethroids. In the present study, the frequency of mutations from An.
Zhang, Hong-wei, Liu, Ying, Hu, Tao, Zhou, Rui-min, Chen, Jian-she, Qian, Dan, Yang, Cheng-yun, Zhao, Yu-ling, Li, Su-hua, Cui, Jing, Wang, Zhong-quan, Feng, Zhanchun, Xu, Bian-li   +12 more
openaire   +2 more sources

Impact of metallothionein-knockdown on cisplatin resistance in malignant pleural mesothelioma [PDF]

Scientific Reports, 2020
AbstractMalignant pleural mesothelioma (MPM) is a rare, but aggressive tumor with dismal prognosis. Platinum-based chemotherapy is regularly used as part of multimodality therapy. The expression of metallothioneins (MT) has been identified as a reason for cisplatin resistance, which often leads to early therapy failure or relapse. Thus, knockdown of MT
Sabrina Borchert, Pia-Maria Suckrau, Robert F. H. Walter, Michael Wessolly, Elena Mairinger, Julia Steinborn, Balazs Hegedus, Thomas Hager, Thomas Herold, Wilfried E. E. Eberhardt, Jeremias Wohlschlaeger, Clemens Aigner, Agnes Bankfalvi, Kurt Werner Schmid, Fabian D. Mairinger   +14 more
openaire   +5 more sources

Insecticide resistance status of Anopheles arabiensis in irrigated and non-irrigated areas in western Kenya

Parasites & Vectors, 2021
Background Malaria control in Kenya is based on case management and vector control using long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS).
Pauline Winnie Orondo, Steven G. Nyanjom, Harrysone Atieli, John Githure, Benyl M. Ondeto, Kevin O. Ochwedo, Collince J. Omondi, James W. Kazura, Ming-Chieh Lee, Guofa Zhou, Daibin Zhong, Andrew K. Githeko, Guiyun Yan   +12 more
doaj   +1 more source

Identification of Knockdown Resistance Mutations in the Cimex hemipterus (Hemiptera: Cimicidae) in Iran. [PDF]

Am J Trop Med Hyg, 2022
ABSTRACT. The worldwide resurgence of tropical bed bug Cimex hemipterus beginning in the late 1990s has led to growing concern. Molecular data on pyrethroid resistance, which is essential for the control strategies, is unknown for C. hemipterus in Iran. The current study evaluated the deltamethrin resistance status of C.
Tiotour M, Shaddel M, Aminianfar M, Mirahmadi H, Barzegar G, Solgi R, Darvishi M.   +6 more
europepmc   +3 more sources