Results 201 to 210 of about 218,644 (293)

Mosquito Feeding Preference, Infectivity Rates, and Knockdown Resistance Within the Wild Population of <i>Anopheles arabiensis</i> in Jabi Tehnan District, Northwest Ethiopia. [PDF]

Trop Med Infect Dis
Bedasso AH, Dugassa S, Deressa JD, Guma GT, Eticha GT, Dangisso MH, Kweka EJ, Tekie H.   +7 more
europepmc   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Molecular forms of the Indian Anopheles subpictus complex differ in their susceptibility to insecticides and the presence of knockdown resistance (kdr) mutations in the voltage-gated sodium channel. [PDF]

PLoS One, 2023
Sindhania A, Lohani HP, Kona MP, Kaur T, Kaushal BR, Singh OP.   +5 more
europepmc   +1 more source

Small Extracellular Vesicles‐Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer

Advanced Science, EarlyView.
sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang, Xueyan Zang, Dongli Wang, Rong Li, Hui Qian, Wenrong Xu, Jiajia Jiang, Yongmin Yan   +7 more
wiley   +1 more source

Differential effects of dual and synergist-based insecticide-treated bed nets on pyrethroid resistance and L995F/S knockdown resistance mutation dynamics in Anopheles gambiae s.l. populations in south-western Burkina Faso. [PDF]

Parasit Vectors
Tapsoba M, Guelbeogo WM, Sanou A, Zongo S, Gogue C, Debe S, Arnett K, Davis K, Shannon J, Digre P, Mwesigwa J, Tynuv K, Fornadel C, N'Falé S, Robertson M, Challenger JD, Tougri G, Gansané A, Ranson H, Olivier G, Wagman J.   +20 more
europepmc   +1 more source

Cancer‐Associated Fibroblasts Promote Tumor Immunosuppression in Hepatocellular Carcinoma via the NNMT‐ANGPTL4 Axis

Advanced Science, EarlyView.
ABSTRACT Background & Aims: Cancer‐associated fibroblasts (CAFs) drive immunosuppression in hepatocellular carcinoma (HCC). However, their metabolic regulation remains poorly defined. We investigated the role of nicotinamide N‐methyltransferase (NNMT) in CAFs. Approach & Results: High NNMT expression in CAF tissues was confirmed by western blotting and
Shounan Lu, Shanjia Ke, Hongjun Yu, Zhanzhi Meng, Miaoyu Bai, Yanan Xu, Hui Zhu, Jinwen Yang, Baolin Qian, Bing Yin, Chaoqun Wang, Zhigang Feng, Zhongyu Li, Yongzhi Zhou, Zihao Li, Xinglong Li, Yongliang Hua, Yao Fu, Wei Tang, Yaohua Wu, Yong Ma   +20 more
wiley   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

Determination of Knockdown Resistance (kdr) Allele Frequencies (T929I mutation) in Head Louse Populations from Mexico, Canada, and Peru. [PDF]

Korean J Parasitol, 2022
Ponce-Garcia G, Villanueva-Segura OK, Garza-Elizondo K, Villegas-Ramirez HM, Fernandez-Salas I, Rodriguez-Sanchez IP, Dzul-Manzanilla F, Flores-Suarez AE.   +7 more
europepmc   +1 more source

Knockdown-resistance (kdr) mutations in Indian Aedes aegypti populations: Lack of recombination among haplotypes bearing V1016G, F1534C, and F1534L kdr alleles. [PDF]

PLoS Negl Trop Dis
Kaur T, Kushwah RS, Pradhan S, Das MK, Kona MP, Anushrita, Mittal R, Weetman D, Dixit R, Singh OP.   +9 more
europepmc   +1 more source

Putative pleiotropic effects of the knockdown resistance (L1014F) allele on the life-history traits of Anopheles gambiae. [PDF]

Malar J, 2021
Medjigbodo AA, Djogbénou LS, Djihinto OY, Akoton RB, Abbey E, Kakossou RM, Sonounameto EG, Salavi EBJ, Djossou L, Badolo A.   +9 more
europepmc   +1 more source