Results 181 to 190 of about 107,528 (262)

Rnd3 regulates lung cancer cell invasion and migration independently of ROCK1 signaling via alpha 5 integrin modulation. [PDF]

Life Sci Alliance
Garcia Garcia N, Nguyen THV, Richey D, Cox EF, Coca Juaristi J, Ashby C, Rodriguez A, Ryan KR.   +7 more
europepmc   +1 more source

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

Advanced Science, EarlyView.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao, Rongji Hui, Zhibo Tang, Tao Feng, Zhihang Hu, Xiaoqing Zhang, Ping Jiang, Hui Zhao, Kwok‐Fai So, Tianyuan Luo, Yanzhou Chang, Lan Yan   +11 more
wiley   +1 more source

ASF1B promotes gastric cancer liver metastasis through inhibiting ZDHHC9/PCBP1/ SLC7A11 signaling axis mediated ferroptosis. [PDF]

NPJ Precis Oncol
Wang M, Yu K, Ma M, Li J, Zhang Y, Ke Z, Wang H, Li Y.   +7 more
europepmc   +1 more source

Knock Knock, Neo

Language Arts Journal of Michigan, 2013
openaire   +3 more sources

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

ARNT2 repression disrupts neuronal identity and promotes glioblastoma growth. [PDF]

Cell Commun Signal
Hao YH, Borenstein-Auerbach N, Grichuk A, Li L, Lafita-Navarro MC, Fang S, Nogueira PA, Kim J, Xu L, Shay JW, Conacci-Sorrell M.   +10 more
europepmc   +1 more source

Graphene (0002)/Diamond (111) Heterojunction with High Piezoresistive Response

Advanced Science, EarlyView.
Graphene/diamond heterostructures show promise as silicon alternatives for semiconductors, but high‐quality integration is challenging. Thermal electron irradiation enables covalent bonding; lonsdaleite acts as an intermediate. The heterostructure exhibits a high piezoresistive response (gauge factor −1149) associated with electron‐rich layers and ...
Xueyu Zhang, Kun Guo, Zhigang Gai, Tianxiao Guo, Yuan Gao, Jiancai Leng, Mei Zhang, Tonggang Jiu, Yibao Wang, Shousheng Liu, Xin Jiang   +10 more
wiley   +1 more source

Motor Protein Disruption Critically Alters Organelle Trafficking and Excitation-Contraction Coupling. [PDF]

eNeuro
Bansal H, Hana TA, Michael AH, Kamaridinova S, Bransford J, Ormerod KG.   +5 more
europepmc   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Targeting circGDI2 disrupt HNRNPC-mediated mPORCN stabilization and enhance LGK-974 anti-tumor therapy in hepatocellular carcinoma. [PDF]

Mol Cancer
Huang Y, Xu L, Yang L, Wu Z, Li L, Dai Y, Dai J, Zhang M, Yi P, Jiang L, Xu M.   +10 more
europepmc   +1 more source