Results 201 to 210 of about 107,528 (262)

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, EarlyView.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source

The Role of NSUN Family Genes in m5C Methylation and Diseases. [PDF]

Biomedicines
Jiang T, Jiang N, Chen X, Xiong Z.
europepmc   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source

Cell- and state-specific plasticity of striatal glutamatergic synapses is critical to the expression of levodopa-induced dyskinesia. [PDF]

Neuron
Shen W, Zhai S, Francardo V, Cui Q, Sun L, Xie Z, Tkatch T, Corredor VE, Lein ES, Ting JT, Cenci MA, Surmeier DJ.   +11 more
europepmc   +1 more source

Knocking for help: a hidden strain of GP training. [PDF]

Br J Gen Pract
Esack H.
europepmc   +1 more source

GPX8 is transcriptionally regulated by KLF16 and promotes osteosarcoma progression. [PDF]

J Transl Med
Dong C, Gao Z, Li X.
europepmc   +1 more source

Mesenchymal stem cells-derived TGF-β1 promotes polarization of M2 macrophages in mice with acute-on-chronic liver failure via FOSL1/MERTK axis. [PDF]

Stem Cell Res Ther
Chen JF, Li ZH, Zhang J, Meng SB, Wang JL, Lei ZY, Wang JY, Wu LL, Zheng Y, Gao ZL, Lin BL.   +10 more
europepmc   +1 more source

LncRNA GAS5 attenuates COPD pathogenesis by stabilizing p120 catenin to suppress NF-κB-driven inflammation. [PDF]

Respir Res
Zhang C, Zhan X, Li Y, Zheng Z, Ji X, Yang L, Wang X.   +6 more
europepmc   +1 more source

FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression. [PDF]

Cell Death Dis
Qin J, Ma S, Wang J, Huang S, Luan J, He J, Hou G, Sun N, Zhang W, Gao M.   +9 more
europepmc   +1 more source