Results 111 to 120 of about 21,998,049 (389)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Mongolia Country Profile [PDF]
, 2003 [From Introduction] This country study for Mongolia is part of the ILO project \u27Employment of People with Disabilities – the Impact of Legislation\u27 which aims to enhance the capacity of national governments in selected countries of Asia and East ...
Infocus Programme on Skills, Knowledge and Employability/Disability Programme +1 more
core +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
, 2017 The European Union is resorting to long-term multi-annual political and economical plans. The current set of plans, “Horizons 2020”, also involves restructuring the educational system, as in the Bologna system.
Fonseca, Custódia +2 more
core
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source
Dimensions of the Smart Home Ontology for Elderly People [PDF]
Iranian Journal of Information Processing & ManagementAccording to the official statistics of the country's population, it is predicted that in the next twenty years, more than a quarter of the population will be elderly.
Najme Nazeri +2 more
doaj +1 more source
Clusters and knowledge: local buzz, global pipelines and the process of knowledge creation
, 2004 The paper is concerned with spatial clustering of economic activity and its relation to the spatiality of knowledge creation in interactive learning processes.
H. Bathelt, A. Malmberg, P. Maskell
semanticscholar +1 more source
Postgraduate boundary crossings? [PDF]
, 2014 This Special Issue: Crossing Philosophical, Cultural and Geographic Boundaries in Educational Scholarship?: Postgraduate Experiences arose out of an invited panel of postgraduate speakers at the 42nd Philosophy of Education Society of Australasia ...
White, Elizabeth Jayne
core +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
A CONTRIBUTION TO OUR KNOWLEDGE OF THE NAEVO-XANTHO-ENDOTHELIOMATA [PDF]
, 1912 J. E. R. McDonagh
openalex +1 more source