Results 121 to 130 of about 21,842,130 (342)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2003 [From Introduction] This country study for Fiji is part of the ILO project \u27Employment of People with Disabilities – the Impact of Legislation\u27 which aims to enhance the capacity of national governments in selected countries of Asia and East Africa
ILO InFocus Programme on Skills, Knowledge and Employability +1 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
, 2003 [From Introduction] This country study for Japan is part of the ILO project \u27Employment of People with Disabilities – the Impact of Legislation\u27 which aims to enhance the capacity of national governments in selected countries of Asia and East ...
InFocus Programme on Skills, Knowledge and Employability +1 more
core +1 more source
TrialsBackground Clinical trial funders aim for trials conducted with high quality, within the planned time and budget. The majority of non-commercial investigator-initiated clinical trials do not complete participant recruitment in time or are discontinued ...
Frank Hulstaert +8 more
doaj +1 more source
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells
FEBS Open Bio, EarlyView.Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori +8 more
wiley +1 more source
Knowledge, Attitude and Practice of Cervical Cancer Screening Through Visual Inspection with Acetic Acid [PDF]
, 2017 Detection of the cervical cancer requires practice of screening that will increase survival rates from the disease. Visual Inspection with Acetic Acid (VIA) is an alternative to screening for cervical cancer.This study aims to assess the knowledge ...
Ahmed, M. K. (Md), Kar, S. (Susmita)
core
, 2017 The article investigates an evidence-based semantics for epistemic logics in which pieces of evidence are interpreted as equivalence relations on the epistemic worlds. It is shown that the properties of knowledge obtained from potentially infinitely many
Naumov, Pavel, Tao, Jia
core +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source