Results 91 to 100 of about 4,480,263 (341)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Regular Expression Based Online Aided Decision Making Knowledge Base for Quality and Security of Food Processing

Cybernetics and Information Technologies, 2015
With regard to the inefficient application of a food processing information system due to shortage of the knowledge acquisition measure and self-updating function of knowledge, a method of constructing an online aided decision making knowledge base for ...
Wen Liu, Peng Liu, Qiang Li, Min Duan, Yan-Rong Wang, Yue Dai   +5 more
doaj   +1 more source

CRC806-KB: A Semantic MediaWiki Based Collaborative Knowledge Base for an Interdisciplinary Research Project

Data, 2018
In the frame of an interdisciplinary research project that is concerned with data from heterogeneous domains, such as archaeology, cultural sciences, and the geosciences, a web-based Knowledge Base system was developed to facilitate and improve research ...
Christian Willmes, Finn Viehberg, Sarah Esteban Lopez, Georg Bareth   +3 more
doaj   +1 more source

Innovation: Exploring the knowledge base [PDF]

New types of knowledge, and new ways of organising the production of it, may emerge as knowledge producers respond to the challenges posed by a changing society.
Jan Fagerberg, Koson Sapprasert
core  

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Development of an Automated Construction Contract Review Framework Using Large Language Model and Domain Knowledge

Buildings
Construction contract review demands specialized expertise, requiring comprehensive understanding of both technical and legal aspects. While AI advancements offer potential solutions, two problems exist: LLMs lack sufficient domain-specific knowledge to ...
Eu Wang Kim, Yeon Ju Shin, Kyong Ju Kim, Sehoon Kwon   +3 more
doaj   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Offline Knowledge Base and Attention-Driven Semantic Communication for Image-Based Applications in ITS Scenarios

Big Data and Cognitive Computing
Communications in intelligent transportation systems (ITS) face explosive data growth from applications such as autonomous driving, remote diagnostics, and real-time monitoring, imposing severe challenges on limited spectrum, bandwidth, and latency ...
Yan Xiao, Xiumei Fan, Zhixin Xie, Yuanbo Lu   +3 more
doaj   +1 more source

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

Molecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo, Carlos M. Martínez‐Cáceres, Manuel Bernabé‐García, Vicente Munitiz, David Ruiz de Angulo, Pascual Parrilla, Ángeles Ortiz, Luisa F. Martínez de Haro, María L. Cayuela   +8 more
wiley   +1 more source

Ontology-based Information Extraction with SOBA [PDF]

, 2011
In this paper we describe SOBA, a sub-component of the SmartWeb multi-modal dialog system. SOBA is a component for ontologybased information extraction from soccer web pages for automatic population of a knowledge base that can be used for domainspecific
Buitelaar, Paul, Cimiano, Philipp, Racioppa, Stefania, Siegel, Melanie   +3 more
core