Results 101 to 110 of about 4,570,213 (290)

Case-based reasoning: The marriage of knowledge base and data base [PDF]

open access: yes
The coupling of data and knowledge has a synergistic effect when building an intelligent data base. The goal is to integrate the data and knowledge almost to the point of indistinguishability, permitting them to be used interchangeably. Examples given in
Casadaban, Cyprian, Pulaski, Kirt
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Perancangan Pengendali Knowledge Base MIMO Pada Turbin Angin [PDF]

open access: yes, 2010
Perancangan pengendali Knowledge Base MIMO pada tubin angin bersumbu horisontal yang fleksibel terhadap kecepatan angin yang berubah-ubah dengan memperoleh nilai daya yang paling maksimal.
Nurwati, T. (Tri)
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Extracting contour lines from topographic maps based on cartography and graphics knowledge

open access: yesJournal of Computer Science and Technology, 2009
This paper addresses the problem of contour line extraction from scanned topographic maps in poor condition. A novel method is developed, using knowledge of cartography and graphics to extract contours by removing other layers which overlay the contours,
Rui-Qing Wu, Xi-Ran Cheng, Cun-Jian Yang
doaj  

CRC806-KB: A Semantic MediaWiki Based Collaborative Knowledge Base for an Interdisciplinary Research Project

open access: yesData, 2018
In the frame of an interdisciplinary research project that is concerned with data from heterogeneous domains, such as archaeology, cultural sciences, and the geosciences, a web-based Knowledge Base system was developed to facilitate and improve research ...
Christian Willmes   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

One Knowledge Base or Many Knowledge Pools? [PDF]

open access: yes
It is increasingly realized that knowledge is the most important resource and that learning is the most important process in the economy. Sometimes this is expressed by coining the current era as characterised by a ‘knowledge based economy’.
Bengt-Åke Lundvall
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Knowledge base methodology: Methodology for first Engineering Script Language (ESL) knowledge base [PDF]

open access: yes
The primary goal of reusing software components is that software can be developed faster, cheaper and with higher quality. Though, reuse is not automatic and can not just happen. It has to be carefully engineered.
Izygon, Michel E., Peeris, Kumar
core   +1 more source

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