Results 101 to 110 of about 1,501,913 (314)
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
Aggressive Behavior, Volume 49, Issue 1, Page 85-95, January 2023., 2023 Abstract The past two decades have produced extensive evidence on the manifold and severe outcomes for victims of aggression exposure in the workplace. However, due to the dominating individual‐centered approach, most findings miss a social network perspective.
Alexander Herrmann +2 more
wiley +1 more source
Internal and External Knowledge Interactive Refinement Framework for Knowledge-Intensive Question Answering [PDF]
arXivRecent works have attempted to integrate external knowledge into LLMs to address the limitations and potential factual errors in LLM-generated content. However, how to retrieve the correct knowledge from the large amount of external knowledge imposes a challenge. To this end, we empirically observe that LLMs have already encoded rich knowledge in their
arxiv
A knowledge base organization for rules about programming [PDF]
, 1977 D Barstow
openalex +1 more source
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Semi‐supervised classification of fundus images combined with CNN and GCN
Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022 Abstract Purpose Diabetic retinopathy (DR) is one of the most serious complications of diabetes, which is a kind of fundus lesion with specific changes. Early diagnosis of DR can effectively reduce the visual damage caused by DR. Due to the variety and different morphology of DR lesions, automatic classification of fundus images in mass screening can ...
Sixu Duan +8 more
wiley +1 more source
A knowledge-based code generator generator [PDF]
, 1977 Christopher W. Fraser
openalex +1 more source
Molecular Oncology, EarlyView.Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti +8 more
wiley +1 more source
Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022 Abstract Entry into the field of clinical medical physics is most commonly accomplished through the completion of a Commission on Accreditation of Medical Physics Educational Programs (CAMPEP)‐accredited graduate and residency program. To allow a mechanism to bring valuable expertise from other disciplines into clinical practice in medical physics, an “
Joann I. Prisciandaro +6 more
wiley +1 more source
Development of science and technology in a knowledge-based organization from the intellectual capital’s perspective [PDF]
مطالعات مدیریت راهبردی, 2020 The foundation of an organization and its transformation into a knowledge organization depend deeply on its various aspects, so that if it is not provided with its basic infrastructure and infrastructure, any attempt at it will fail.
mohammad reza zahedi +2 more
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