Results 71 to 80 of about 1,501,913 (314)

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source

Logically automorphically equivalent knowledge bases [PDF]

arXiv, 2017
Knowledge bases theory provide an important example of the field where applications of universal algebra and algebraic logic look very natural, and their interaction with practical problems arising in computer science might be very productive. In this paper we study the equivalence problem for knowledge bases.
arxiv  

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Using Graph Pattern Association Rules on Yago Knowledge Base

Journal of ICT Research and Applications, 2019
The use of graph pattern association rules (GPARs) on the Yago knowledge base is proposed. Extending association rules for itemsets, GPARS can help to discover regularities between entities in a knowledge base.
Wahyudi Wahyudi, Masayu Leylia Khodra, Ary Setijadi Prihatmanto, Carmadi Machbub   +3 more
doaj   +1 more source

GEOEssential – mainstreaming workflows from data sources to environment policy indicators with essential variables

International Journal of Digital Earth, 2020
When defining indicators on the environment, the use of existing initiatives should be a priority rather than redefining indicators each time. From an Information, Communication and Technology perspective, data interoperability and standardization are ...
Anthony Lehmann, Stefano Nativi, Paolo Mazzetti, Joan Maso, Ivette Serral, Daniel Spengler, Aidin Niamir, Ian McCallum, Pierre Lacroix, Petros Patias, Denisa Rodila, Nicolas Ray, Grégory Giuliani   +12 more
doaj   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Knowledge Acquisition for Diagnosis of Skin Diseases as an Initial Platform for an Expert System

Journal of Health Management & Informatics, 2018
Background: The diagnosis of skin diseases, especially in patients suffering from more than one disease or having similar symptoms, is very complex and access to the knowledge of skin diseases makes the design of an expert system easier.
Fatemeh Rangraz Jeddi, Masoud Arabfard, Zahra Arab Kermani   +2 more
doaj  

Formation and Development of Intellectual Systems of Self-servicing: Basic Definitions Формирование и развитие интеллектуальных систем самообслуживания: базовые определения [PDF]

Bìznes Inform, 2013
The article considers problems of formation of systems of self-servicing of customers. These processes take place in different branches of service and are determined by development of information technologies.
Kuzmin Pavel P.
doaj