Results 111 to 120 of about 6,326,238 (294)

From knowledge presentation to knowledge representation to knowledge construction: Future directions for hypermedia [PDF]

open access: yes
Relationships between human memory systems and hypermedia systems are discussed with particular emphasis on the underlying importance of associational memory.
Palumbo, David B.
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

Intelligent Support for a Computer Aided Design Optimisation Cycle

open access: yesActa Polytechnica, 2006
It is becoming more and more evident that  adding intelligence  to existing computer aids, such as computer aided design systems, can lead to significant improvements in the effective and reliable performance of various engineering tasks, including ...
B. Dolšak, M. Novak, J. Kaljun
doaj  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Modelo de Sistema Basado en Conocimiento para Apoyo en la Investigación y Proceso Clínico de la Diabetes

open access: yesRevista Colombiana de Biotecnología, 2012
Debido a la gran cantidad de información generada y apoyada por la evolución explosiva de sistemas de la ciencia computacional, desde finales del siglo pasado, la expansión y transferencia de conocimiento científico ha provocado una rápida ...
Alfonso Hernández-Medrano   +3 more
doaj  

Domain‐adaptation‐based named entity recognition with information enrichment for equipment fault knowledge graph

open access: yesIET Collaborative Intelligent Manufacturing
Numerous files, such as records and logs, are generated in the process of equipment diagnosis and maintenance (D&M). These files contain lots of unstructured plain text. Knowledge in these files could be reused for similar equipment faults.
Dengrui Xiong   +3 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Use of metaknowledge in the verification of knowledge-based systems [PDF]

open access: yes
Knowledge-based systems are modeled as deductive systems. The model indicates that the two primary areas of concern in verification are demonstrating consistency and completeness.
Morell, Larry J.
core   +1 more source

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