Results 101 to 110 of about 6,326,238 (294)

ADAM-1: An AI Reasoning and Bioinformatics Model for Alzheimer’s Disease Detection and Microbiome-Clinical Data Integration

IEEE Access
Alzheimer’s Disease Analysis Model Generation 1 (ADAM-1) is a multi-agent reasoning large language model (LLM) framework designed to integrate and analyze multimodal data, including microbiome profiles, clinical datasets, and external knowledge ...
Ziyuan Huang, Vishaldeep Kaur Sekhon, Roozbeh Sadeghian, Maria L. Vaida, Cynthia Jo, Beth A. McCormick, Doyle V. Ward, Vanni Bucci, John P. Haran   +8 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Feasibility of using a knowledge-based system concept for in-flight primary flight display research [PDF]

A study was conducted to determine the feasibility of using knowledge-based systems architectures for inflight research of primary flight display information management issues.
Ricks, Wendell R.
core   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Knowledge acquisition for case-based reasoning systems [PDF]

Case-based reasoning (CBR) is a simple idea: solve new problems by adapting old solutions to similar problems. The CBR approach offers several potential advantages over rule-based reasoning: rules are not combined blindly in a search for solutions ...
Riesbeck, Christopher K.
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Toward integration of knowledge based systems and knowledge discovery systems

Journal of Computer Science and Technology, 2007
This paper presents a proposal for an architecture that integrates knowledge discovery systems (automatic acquisition) and knowledge based systems (experts systems).
Claudio Rancan, Patricia Mabel Pesado, Ramón García Martínez   +2 more
doaj  

Applying knowledge compilation techniques to model-based reasoning [PDF]

Researchers in the area of knowledge compilation are developing general purpose techniques for improving the efficiency of knowledge-based systems. In this article, an attempt is made to define knowledge compilation, to characterize several classes of ...
Keller, Richard M.
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Taxonomy and Survey on Cybersecurity Control Schemes for Smart Grids

IET Smart Grid
This article presents a comprehensive taxonomy and survey of Cybersecurity Control Schemes (CCS) tailored for Smart Grids (SG), with a particular focus on vulnerabilities in the IEC 61850 standard and the countermeasures provided by IEC 62351.
Aldo Insfrán, Fabio López‐Pires, Benjamín Barán   +2 more
doaj   +1 more source