Results 81 to 90 of about 34,204,469 (282)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Design issues for knowledge artifacts

, 2008
The notion of knowledge artifact has rapidly gained popularity in the fields of general knowledge management and more recently knowledge-based systems. The main goal on this paper is to propose and discuss a methodology for the design and implementation ...
BANDINI, S., NORIEGA, C. A., COLOMBO, E., SILVA, F. S. Correa Da, SALAZAR-TORRES, G.   +4 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Agent-based formation of virtual organisations

, 2004
Virtual organisations (VOs) are composed of a number of individuals, departments or organisations each of which has a range of capabilities and resources at their disposal. These VOs are formed so that resources may be pooled and services combined with a
Preece, A., Fiddian, Nicholas John, Luck, M, Luck, Michael; id_orcid, Nguyen, Thuc Duong, Nguyen, Thuc D., Nguyen, T.D., Chalmers, S, Preece, A, Luck, Michael, Deora, Vikas, Jennings, N. R., Fiddian, N., Jennings, NR, Gray, A, Norman, Timothy, Preece, Alun D., Dang, Viet D., Dang, V.D., Fiddian, Nick J., Preece, Alun David, Deora, V., Norman, Timothy J., Shao, Jianhua, Gray, William Alexander, Fiddian, N, Dang, Viet Dung, Deora, V, Gray, W. Alex, Nguyen, TD, Chalmers, Stuart, Jennings, N.R., Norman, TJ, Shao, J, Jennings, Nicholas R., Chalmers, S., Gray, A., Dang, VD, Shao, J., Luck, M.   +39 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A knowledge based formal language for securing information systems

, 2009
In this paper, we propose a formal logic approach to specify the system security policies and rules and their reasoning in response to queries of accessing the system resource. Especially we investigate and handle the situation where the security agent's
Yun Bai, Bai, Yun (R7233)
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A concurrent dynamic logic of knowledge, belief and certainty for multi-agent systems

, 2010
This paper extends the logic of knowledge, belief and certainty from one agent to multi-agent systems, and gives a good combination between logic of knowledge, belief, certainty in multi-agent systems and actions that have concurrent and dynamic ...
Su, Kaile, Su, Jinshu, Luo, Xiangyu, Yang, Zhihua, Wu, Lijun   +4 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Domain‐adaptation‐based named entity recognition with information enrichment for equipment fault knowledge graph

IET Collaborative Intelligent Manufacturing
Numerous files, such as records and logs, are generated in the process of equipment diagnosis and maintenance (D&M). These files contain lots of unstructured plain text. Knowledge in these files could be reused for similar equipment faults.
Dengrui Xiong, Xinyu Li, Liang Gao, Yiping Gao   +3 more
doaj   +1 more source