Results 71 to 80 of about 34,204,469 (282)

Knowledge evaluation in product lifecycle design and support [PDF]

, 2014
Enterprises are focusing more and more on knowledge issues for global product development. This paper describes knowledge evolution processes in product development activities and proposes a knowledge evaluation method in product lifecycle design.
SUGIMOTO, Shigeo, XU, Yang, BERNARD, Alain, PERRY, Nicolas, XU, Jing   +4 more
core   +1 more source

Semantically Enhanced Medical Information Retrieval System: A Tensor Factorization Based Approach

IEEE Access, 2017
Medical information retrieval plays an increasingly important role to help physicians and domain experts to better access medical-related knowledge and information, and support decision making. Integrating the medical knowledge bases has the potential to
Haolin Wang, Qingpeng Zhang, Jiahu Yuan
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Meeting the Need for Knowledge Management in Schools with Knowledge-Based Systems - A Case Study

, 2005
Usually the aim with knowledge management is to increase the profit, through capturing, storing, sharing, and utilising knowledge in an innovative way. Can knowledge management be of use in organisations as schools, where profit is of no interest?
Edman, Anneli,
core  

Modeling State Causality in Energy Centred Cyber-Physical-Human Systems With OntoUML

IEEE Access
Energy-focused Cyber-Physical-Human Systems (CPHSs) depend on understanding how events, states, and temporal transitions shape system behaviour, particularly in settings where human actors, such as building occupants, grid operators, and domain experts ...
Mohammad Bilal, Katrin Ehrenmuller, Gernot Steindl, Zhuoxun Zheng, Shqiponja Ahmetaj, Ahmet Soylu, Emanuel Sallinger, Wolfgang Kastner   +7 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

ADAM-1: An AI Reasoning and Bioinformatics Model for Alzheimer’s Disease Detection and Microbiome-Clinical Data Integration

IEEE Access
Alzheimer’s Disease Analysis Model Generation 1 (ADAM-1) is a multi-agent reasoning large language model (LLM) framework designed to integrate and analyze multimodal data, including microbiome profiles, clinical datasets, and external knowledge ...
Ziyuan Huang, Vishaldeep Kaur Sekhon, Roozbeh Sadeghian, Maria L. Vaida, Cynthia Jo, Beth A. McCormick, Doyle V. Ward, Vanni Bucci, John P. Haran   +8 more
doaj   +1 more source

Rule-based classification of energy theft and anomalies in consumers load demand profile

IET Smart Grid, 2019
The invent of advanced metering infrastructure (AMI) opens the door for a comprehensive analysis of consumers consumption patterns including energy theft studies, which were not possible beforehand. This study proposes a fraud detection methodology using
Sonal Jain, Kushan A. Choksi, Naran M. Pindoriya   +2 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source