Results 111 to 120 of about 1,689,886 (311)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Internal orientation in the growth of Born-Globals. Learning from inside [PDF]

, 2018
Este paper ha recibido dos premios en el congreso: 1. Thomson South-Western Award OUTSTANDING RESEARCH-BASED PAPER ON MANAGEMENT CONSULTING 2. FINALIST CAROLYN DEXTER AWARD FOR BEST INTERNATIONAL PAPERBased on a longitudinal case study in a young ...
Martín-Armario, Julia, Rastrollo-Horrillo, Maria Angeles   +1 more
core  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Premises, practices and politics of co-creation for urban sustainability transitions

Urban Transformations
Co-creation is becoming a widely used mode of urban governance and research for city-making and city-transitioning being conceptually entangled with experimentation, innovation and collaboration.
Niki Frantzeskaki, Marcus Collier, Katharina Hölscher, Idil Gaziulusoy, Alessandro Ossola, Patricia Albulescu, Marcelline Bonneau, Sara Borgstrom, Stuart Connop, Adina Dumitru, Davide Geneletti, Leen Gorissen, Meike Levin-Keitel, Tadhg MacIntyre, Irina Mascinga, Siobhan McQuaid, Samuel Tabory, Timo von Wirth, Paula Vandergert, Peter Vos, Gil Penha-Lopes, Ina Säumel, Thomas Wachtel, Julia Wittmayer   +23 more
doaj   +1 more source

Cross-border Market Co-creation, Dynamic Capabilities and the Entrepreneurial Theory of the Multinational Enterprise [PDF]

The concepts of asset co-specialization and dynamic capabilities have been instrumental in furthering the organization and strategy scholarship agenda, but have so far had limited impact to the theory of the MNE and FDI.
Pitelis, Christos, Teece, David
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Exploring factors that influence customer engagement in value co-creation in higher education institutions using online platforms [PDF]

, 2016
Higher Education Institutions (HEIs) can be described as a container that encompasses strong knowledgeable minds and experienced individuals. It is one of the service sectors comprised of a huge number of individuals who are attached for life with Higher
Hasan, N., Rahman, A. A.
core  

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Bridging the gap: reflections on co-creation in knowledge translation

Research Involvement and Engagement
Background To address the research-practice gap, knowledge translation is a crucial step in which co-creation, including patient and public involvement (PPI), is key.
Marjolijn Ketelaar, Maureen Bult, Marike Willems-op Het Veld, Karen van Meeteren, Marij Roebroeck, Jeanine Voorman   +5 more
doaj   +1 more source