Results 71 to 80 of about 729,240 (267)

Intelligent harmonic diagnosis and tracing method for urban power grids via cross-modal fusion of time-frequency features and unstructured equipment records

Frontiers in Energy Research
Against the backdrop of the accelerated construction of new electricity systems and the continuous increase in the proportion of power electronicization, urban power grid harmonics exhibit characteristics such as multi-source, time-varying, and wide-area
Zhiwen Yu, Yanliang Dan, Yueting Lin, Zhanqiang Xu   +3 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Morphology-Aware Multi-Scale Deep Representation Learning for Interpretable Knowledge Extraction in Brain Tumor MRI

Machine Learning and Knowledge Extraction
Robust brain tumor classification from magnetic resonance imaging (MRI) remains challenging due to complex structural heterogeneity and subtle inter-class variability.
Helala AlShehri, Mariam Busaleh
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A Modular Knowledge-Extraction Framework for Deep Learning Forecasts of Multi-Tier Commodity Prices

Machine Learning and Knowledge Extraction
Vertically linked commodity markets—global futures, regional spot, and farm-gate prices—transmit information through directed cross-market channels whose strength varies with latent volatility regimes.
Montchai Pinitjitsamut
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Top-Weighted Structural Analysis of Ordered List Averaging for Medical Knowledge Extraction

Mathematics
Ordered List Averaging (OLA) was previously introduced as a methodology for evaluating machine learning algorithms according to their ability to prioritize medically relevant feature subsets.
Ricardo Sánchez-de-Madariaga, Mario Pascual Carrasco, Adolfo Muñoz Carrero   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Extracting Learning Data From Handwritten Notes: A New Approach to Educational Data Analysis Based on Image Segmentation and Generative AI

IEEE Access
While handwritten notes offer valuable insights into students’ knowledge retention, traditional analysis methods are often time-consuming and limited in scope.
Yunyu Zhou, Cheng Tang, Atsushi Shimada
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source