Results 211 to 220 of about 8,023,305 (265)

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Explainable AI augmented retailer segmentation using knowledge graph. [PDF]

Sci Rep
Shiralkar K, Bongale A, Kumar S, Warke V, Deshmukh R.   +4 more
europepmc   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

The ROBOKOP v1.0 knowledge graph system for exploring relationships between biomedical entities. [PDF]

Sci Rep
Fecho K, Morris E, Beasley JM, Carter EK, Chung CH, Edwards S, Glymph D, Korn D, Olasunkanmi O, Pasfield C, Ramon M, Richardson J, Tucker N, Williams D, Zheng W, Tropsha A, Bizon C.   +16 more
europepmc   +1 more source

Studies on Counter Electrode Materials in Aqueous Zinc Half‐Cell Configurations

Advanced Science, EarlyView.
Coulombic efficiency is a key metric for zinc reversibility in aqueous zinc‐ion batteries, but its reliability in zinc half‐cells is strongly influenced by poorly understood counter‐electrode materials. By systematically comparing Cu, Ti, stainless steel, and Al to identify reactions associated with current collectors, we find that Ti is the metal ...
Peiming Chen, Ruwei Chen, Xuhuan Xiao, Zhe Cui, Guanjie He   +4 more
wiley   +1 more source

NeuroCypher ASD: Machine Learning with Knowledge Graph-Based Representation for ASD Screening in Toddlers. [PDF]

J Healthc Inform Res
Bouchouras G, Doumanas D, Kotis K.
europepmc   +1 more source

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

A knowledge graph-guided transcriptomic framework identifies a 20-gene prognostic signature for cervical cancer. [PDF]

BMC Bioinformatics
Deng Z, Bi X, Zhang H.
europepmc   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

KGAP: An RDF knowledge graph of agricultural commodity prices. [PDF]

Data Brief
Soares FM, Ferreira Pires L, Corrêa FE, Bonino da Silva Santos LO, Braghetto KR, Moreira DA, Drucker DP, Delbem ACB, Saraiva AM.   +8 more
europepmc   +1 more source