Results 51 to 60 of about 1,488,586 (258)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

ArCo: the Italian Cultural Heritage Knowledge Graph

open access: yes, 2019
ArCo is the Italian Cultural Heritage knowledge graph, consisting of a network of seven vocabularies and 169 million triples about 820 thousand cultural entities.
A Gangemi   +14 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Research and application practice of knowledge graph technology system for telecom-operators

open access: yesDianxin kexue, 2022
Knowledge graph plays an important role in knowledge search, work order processing, intelligent service, fault analysis and other fields of China Mobile business and maintenance scenario.The knowledge graph technology system of China Mobile was ...
Dongming ZHAO
doaj   +2 more sources

Knowledge graph analysis of particles in Japanese [PDF]

open access: yes, 2005
The theory of knowledge graphs is a structuralistic theory of language. Its ontology consists of eight types of binary relationships and four types of so-called frames. The relationships connect so-called tokens, that represent semantic units.
Hoede, C.
core   +1 more source

KGAT: Knowledge Graph Attention Network for Recommendation

open access: yes, 2019
To provide more accurate, diverse, and explainable recommendation, it is compulsory to go beyond modeling user-item interactions and take side information into account.
Cao, Yixin   +4 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Scene Graph Generation with External Knowledge and Image Reconstruction

open access: yes, 2019
Scene graph generation has received growing attention with the advancements in image understanding tasks such as object detection, attributes and relationship prediction,~\etc.
Cai, Jianfei   +5 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Research on Service Discovery Methods Based on Knowledge Graph

open access: yesIEEE Access, 2020
Service discovery is one of the main goals of a service-oriented architecture, helping to discover complex applications. Knowledge graph is a cross-cutting research hotspot in the fields of computer, knowledge engineering and information science.
Li Guodong   +3 more
doaj   +1 more source

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