Results 81 to 90 of about 290,132 (291)
Key technologies and research progress of medical knowledge graph construction
大数据, 2021 With the continuous iterative updating of Internet technology, the semantic understanding of massive data is becoming more and more important.Knowledge graph is a kind of semantic network that reveals the relationship between entities.Medicine is one of ...
Ling TAN +10 more
doaj
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Semantic-Enhanced Knowledge Graph Completion
MathematicsKnowledge graphs (KGs) serve as structured representations of knowledge, comprising entities and relations. KGs are inherently incomplete, sparse, and have a strong need for completion.
Xu Yuan +6 more
doaj +1 more source
Knowledge Representation through Graphs
Procedia Computer Science, 2015 AbstractDue to the increasing amount of data, knowledge aggregation, representation and reasoning are highly important for companies. In this paper, knowledge aggregation is presented as the first step. In the sequel, successful knowledge representation, for instance through graphs, enables knowledge-based reasoning.
Edy Portmann +4 more
openaire +2 more sources
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Knowledge Graph Essentials and Key Technologies
Современные информационные технологии и IT-образование, 2019 In recent decades, the amount of information that humankind has accumulated has increased tremendously. People cannot analyze it effectively using simple algorithms, and data structures due to these approaches do not understand the se¬mantics of the data.
Vladislav Gurin +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
Knowledge Graphs on the Web – An Overview
, 2020 Knowledge Graphs are an emerging form of knowledge representation. While Google coined the term Knowledge Graph first and promoted it as a means to improve their search results, they are used in many applications today. In a knowledge graph, entities in the real world and/or a business domain (e.g., people, places, or events) are represented as nodes ...
Heist, Nicolas +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source