Results 81 to 90 of about 7,291,916 (317)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Research on Service Discovery Methods Based on Knowledge Graph
IEEE Access, 2020 Service discovery is one of the main goals of a service-oriented architecture, helping to discover complex applications. Knowledge graph is a cross-cutting research hotspot in the fields of computer, knowledge engineering and information science.
Li Guodong +3 more
doaj +1 more source
Knowledge graph analysis of particles in Japanese [PDF]
, 2005 The theory of knowledge graphs is a structuralistic theory of language. Its ontology consists of eight types of binary relationships and four types of so-called frames. The relationships connect so-called tokens, that represent semantic units.
Hoede, C.
core +1 more source
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
A Quick Prototype for Assessing OpenIE Knowledge Graph-Based Question-Answering Systems
Information, 2023 Due to the rapid growth of knowledge graphs (KG) as representational learning methods in recent years, question-answering approaches have received increasing attention from academia and industry.
Giuseppina Di Paolo +2 more
doaj +1 more source
Scene Graph Generation with External Knowledge and Image Reconstruction
, 2019 Scene graph generation has received growing attention with the advancements in image understanding tasks such as object detection, attributes and relationship prediction,~\etc.
Cai, Jianfei +5 more
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Knowledge Graph Convolutional Networks for Recommender Systems [PDF]
The Web Conference, 2019 To alleviate sparsity and cold start problem of collaborative filtering based recommender systems, researchers and engineers usually collect attributes of users and items, and design delicate algorithms to exploit these additional information. In general,
Hongwei Wang +4 more
semanticscholar +1 more source