Results 241 to 250 of about 468,662 (346)

Research on Traditional Chinese Medicine: Domain Knowledge Graph Completion and Quality Evaluation.

JMIR Med Inform
Liu C, Li Z, Li J, Qu Y, Chang Y, Han Q, Cao L, Lin S.   +7 more
europepmc   +1 more source

Knowledge graph for traditional Chinese medicine diagnosis and treatment of diabetic retinopathy: design, construction, and applications. [PDF]

Int J Ophthalmol
Xiao L, Wang JW, Wang CW, Wang Y, Yan JF, Peng QH.   +5 more
europepmc   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Multi-omics modality completion and knowledge distillation for drug response prediction in cervical cancer. [PDF]

Front Oncol
Li D, Yan B, Liao K, Huang J, Zhang J, Chen Y, Zhu J, Zhi S, Chen L.   +8 more
europepmc   +1 more source

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

Advanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao Chen   +8 more
wiley   +1 more source

Variational adversarial negative sampling for multimodal knowledge graph completion

H. Miao, Yong Feng, Yuanlin Chen, Guangyao Duan, Baohua Qiang, Mingliang Zhou   +5 more
openalex   +1 more source

Knowledge graph-based intelligent data management and information innovation service model for university library systems. [PDF]

PLoS One
Liu F.
europepmc   +1 more source

DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss

Advanced Science, EarlyView.
Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim, Kridtapat Sirisereephap, Hui Wang, Giulia Trimaglio, Kyoung‐Jin Chung, Jonathan Korostoff, Tetsuhiro Kajikawa, Xiaofei Li, Meircurius D.C. Surboyo, Tomoki Maekawa, Triantafyllos Chavakis, George Hajishengallis   +11 more
wiley   +1 more source

An explainable path reasoning framework for knowledge graph completion

Haiyang Yu, Hong Yu, Wei Wang, Kai Fang, Xiaotong Zhang, Han Liu   +5 more
openalex   +1 more source

ColKGC: Collaborative Enhancement using Large Language Model for Knowledge Graph Completion [PDF]

Heng Fang
openalex   +1 more source