Results 61 to 70 of about 34,792 (262)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

ShallowBKGC: a BERT-enhanced shallow neural network model for knowledge graph completion [PDF]

PeerJ Computer Science
Knowledge graph completion aims to predict missing relations between entities in a knowledge graph. One of the effective ways for knowledge graph completion is knowledge graph embedding.
Ningning Jia, Cuiyou Yao
doaj   +2 more sources

Hamming Distance Encoding Multihop Relation Knowledge Graph Completion

IEEE Access, 2020
Knowledge graphs (KGs) play an important role in many real-world applications like information retrieval, question answering, relation extraction, etc. To reveal implicit knowledge from a knowledge graph (KG), viz.
Panfeng Chen, Yisong Wang, Quan Yu, Yi Fan, Renyan Feng   +4 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Federated Learning FedLTailor: A Dynamic Weight Adjustment and Personalized Fusion Approach

IEEE Access
In this study, we primarily address the issue of uneven quality of client embeddings in existing federated learning frameworks for knowledge graph completion.
Hong Zheng, Shanqin Li
doaj   +1 more source

Contextual Dictionary Lookup for Knowledge Graph Completion

CoRR, 2023
Knowledge graph completion (KGC) aims to solve the incompleteness of knowledge graphs (KGs) by predicting missing links from known triples, numbers of knowledge graph embedding (KGE) models have been proposed to perform KGC by learning embeddings. Nevertheless, most existing embedding models map each relation into a unique vector, overlooking the ...
Jining Wang, Delai Qiu, Youming Liu, Yining Wang, Chuan Chen 0001, Zibin Zheng, Yuren Zhou   +6 more
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

DFedKG: Diffusion-Based Federated Knowledge Graph Completion

Data Science and Engineering
In recent years, the task of knowledge graph completion has attracted significant attention from researchers. In practical scenarios, multi-source knowledge graph completion is quite common.
Chao Zhao, Yurong Cheng, Boyang Li, Yi Yang, Xue Wang   +4 more
doaj   +1 more source