Results 71 to 80 of about 35,565 (288)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Translation-Based Embeddings with Octonion for Knowledge Graph Completion

Applied Sciences, 2022
Knowledge representation learning achieves the automatic completion of knowledge graphs (KGs) by embedding entities into continuous low-dimensional vector space.
Mei Yu, Chen Bai, Jian Yu, Mankun Zhao, Tianyi Xu, Hongwei Liu, Xuewei Li, Ruiguo Yu   +7 more
doaj   +1 more source

Improving Hyper-Relational Knowledge Graph Completion

CoRR, 2021
Different from traditional knowledge graphs (KGs) where facts are represented as entity-relation-entity triplets, hyper-relational KGs (HKGs) allow triplets to be associated with additional relation-entity pairs (a.k.a qualifiers) to convey more complex information.
Donghan Yu, Yiming Yang 0002
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Knowledge graph completion method based on hyperbolic representation learning and contrastive learning

Egyptian Informatics Journal, 2023
Knowledge graph completion employs existing triples to deduce missing data, thereby enriching and enhancing graph completeness. Recent research has revealed that using hyperbolic representation learning in knowledge graph completion yields superior ...
Xiaodong Zhang, Meng Wang, Xiuwen Zhong, Feixu An   +3 more
doaj   +1 more source

Contextual Dictionary Lookup for Knowledge Graph Completion

CoRR, 2023
Knowledge graph completion (KGC) aims to solve the incompleteness of knowledge graphs (KGs) by predicting missing links from known triples, numbers of knowledge graph embedding (KGE) models have been proposed to perform KGC by learning embeddings. Nevertheless, most existing embedding models map each relation into a unique vector, overlooking the ...
Jining Wang, Delai Qiu, Youming Liu, Yining Wang, Chuan Chen 0001, Zibin Zheng, Yuren Zhou   +6 more
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Augmenting Embedding Projection With Entity Descriptions for Knowledge Graph Completion

IEEE Access, 2021
Extra information, such as hierarchical entity types, entity descriptions or some text corpus are recently used to enhance Knowledge Graph Completion (KGC).
Junfan Chen, Jie Xu, Manhui Bo, Hongwu Tang   +3 more
doaj   +1 more source

Knowledge graph completion for scholarly knowledge graph

Bulletin of Social Informatics Theory and Application
Scholarly knowledge graph is a knowledge graph that is used to represent knowledge contained in scientific publication documents. The information we can find in a scientific publication document is as follows: author, institution, name of journal/conference, and research topic. A knowledge graph that has been built is usually still not perfect.
Taufiqurrahman Taufiqurrahman, Kemas Rahmat Saleh Wiharja, Gia Septiana Wulandari   +2 more
openaire   +1 more source