Results 61 to 70 of about 622,196 (281)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
A Shared Ontology Approach to Semantic Representation of BIM Data [PDF]
, 2017 Architecture, engineering, construction and facility management (AEC-FM) projects involve a large number of participants that must exchange information and combine their knowledge for successful completion of a project.
Karshenas, Saeed, Niknam, Mehrdad
core +1 more source
A Complete Generalized Adjustment Criterion [PDF]
, 2015 Covariate adjustment is a widely used approach to estimate total causal effects from observational data. Several graphical criteria have been developed in recent years to identify valid covariates for adjustment from graphical causal models.
Kalisch, Markus +3 more
core +4 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Building a Knowledge Base of Bridge Maintenance Using Knowledge Graph
Advances in Civil Engineering, 2023 To effectively manage the heterogeneous and discrete knowledge of the bridge maintenance domain, this study adopts knowledge graph technology to build a knowledge base of bridge maintenance, called the bridge maintenance knowledge graph (BMKG).
Yang Zhang, Jia Liu, Kepeng Hou
doaj +1 more source
Research on the construction and implementation of power grid fault handling knowledge graphs
Energy Reports, 2023 Power grid fault disposal has important guiding significance for the efficient and orderly emergency work of power grid accidents. The knowledge graph technology is used to extract, express and manage the fault disposal information.
Na Xiao +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
IEEE Access, 2019 Since first coined by Google in 2012, knowledge graph has received extensive attention from both industry and academia, and has been widely used in many scenarios with success, e.g. information retrieval, online recommendation, question-answering, and so
Shuai Wang +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source