Results 61 to 70 of about 1,050,353 (272)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Semantic Web: Past, Present, and Future [PDF]

Transactions on Graph Data and Knowledge
Ever since the vision was formulated, the Semantic Web has inspired many generations of innovations. Semantic technologies have been used to share vast amounts of information on the Web, enhance them with semantics to give them meaning, and enable ...
Scherp, Ansgar, Groener, Gerd, Škoda, Petr, Hose, Katja, Vidal, Maria-Esther   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Research on Hierarchical Knowledge Graphs of Data, Information, and Knowledge Based on Multiple Data Sources

Applied Sciences, 2023
In the existing medical knowledge graphs, there are problems concerning inadequate knowledge discovery strategies and the use of single sources of medical data.
Menglong Li, Zehao Ni, Le Tian, Yuxiang Hu, Juan Shen, Yu Wang   +5 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Multi-task Neural Network for Non-discrete Attribute Prediction in Knowledge Graphs

, 2017
Many popular knowledge graphs such as Freebase, YAGO or DBPedia maintain a list of non-discrete attributes for each entity. Intuitively, these attributes such as height, price or population count are able to richly characterize entities in knowledge ...
Bollacker Kurt D., Diederik, Guo Shu, Gupta Abhijeet, Hoffart Johannes, Jenatton Rodolphe, Ji Guoliang, Li Ya, Lin Yankai, Lin Yankai, Lin Yankai, Liu Pengfei, Luu Anh Tuan, Mikolov Tomas, Nickel Maximilian, Qiu Xipeng, Tay Yi, Wang Zhen, Xiao Han, Xie Ruobing, Zhong Huaping   +20 more
core   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Knowledge graph completion for scholarly knowledge graph

Bulletin of Social Informatics Theory and Application
Scholarly knowledge graph is a knowledge graph that is used to represent knowledge contained in scientific publication documents. The information we can find in a scientific publication document is as follows: author, institution, name of journal/conference, and research topic. A knowledge graph that has been built is usually still not perfect.
Taufiqurrahman Taufiqurrahman, Kemas Rahmat Saleh Wiharja, Gia Septiana Wulandari   +2 more
openaire   +1 more source

Cybersecurity knowledge graphs construction and quality assessment

Complex & Intelligent Systems, 2023
Cyber-attack activities are complex and ever-changing, posing severe challenges to cybersecurity personnel. Introducing knowledge graphs into the field of cybersecurity helps depict the intricate cybersecurity landscape and provides technical support for
Hongyi Li, Ze Shi, Chengwei Pan, Di Zhao, Nan Sun   +4 more
doaj   +1 more source