Results 81 to 90 of about 247,759 (306)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Semantic Web: Past, Present, and Future [PDF]

Transactions on Graph Data and Knowledge
Ever since the vision was formulated, the Semantic Web has inspired many generations of innovations. Semantic technologies have been used to share vast amounts of information on the Web, enhance them with semantics to give them meaning, and enable ...
Scherp, Ansgar, Groener, Gerd, Škoda, Petr, Hose, Katja, Vidal, Maria-Esther   +4 more
doaj   +1 more source

Research on Hierarchical Knowledge Graphs of Data, Information, and Knowledge Based on Multiple Data Sources

Applied Sciences, 2023
In the existing medical knowledge graphs, there are problems concerning inadequate knowledge discovery strategies and the use of single sources of medical data.
Menglong Li, Zehao Ni, Le Tian, Yuxiang Hu, Juan Shen, Yu Wang   +5 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Cybersecurity knowledge graphs construction and quality assessment

Complex & Intelligent Systems, 2023
Cyber-attack activities are complex and ever-changing, posing severe challenges to cybersecurity personnel. Introducing knowledge graphs into the field of cybersecurity helps depict the intricate cybersecurity landscape and provides technical support for
Hongyi Li, Ze Shi, Chengwei Pan, Di Zhao, Nan Sun   +4 more
doaj   +1 more source

Modularization Method to Reuse Medical Knowledge Graphs

Applied Sciences, 2022
During the creation and integration of a health care system based on medical knowledge graphs, it is necessary to review and select the vocabularies and definitions that best fit the information requirements of the system being developed.
Maricela Bravo, Darinel González-Villarreal, José A. Reyes-Ortiz, Leonardo D. Sánchez-Martínez   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Educational Knowledge Graph: Research Progress and Future Development—Analysis of Articles Published in Core Chinese Journals from 2013 to 2023 [PDF]

Jisuanji gongcheng
The deep integration of knowledge graphs with education has promoted the development of smart education. However, there is a lack of literature on educational knowledge graphs currently, necessitating its improvement with regard to research normativity ...
Huiqian LI, Baichang ZHONG
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source