Results 181 to 190 of about 302,884 (283)

Single‐Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment

open access: yesAdvanced Science, EarlyView.
This study uses single‐nucleus RNA sequencing and spatial transcriptomics to investigate penile squamous cell carcinoma (PSCC). It reveals that PSCC tumor cells mimic normal penile epithelium differentiation, independent of HPV status. The Tum_1 subtype shows basal stem‐like characteristics and promotes invasiveness. HPV‐positive basal stem‐like tumors
Hongjian Song   +37 more
wiley   +1 more source

A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing

open access: yesAdvanced Science, EarlyView.
This study discoveries that EBV EBNA1 behaves as a prion‐like protein, verified using cell‐based assays and the Saccharomyces cerevisiae Sup35p prion identification system. The prion‐like domain of EBNA1 drives liquid–liquid phase separation. EBNA1 interacts with the splicing factor SRSF1 to regulate the expression of the SRRM1 splicing isoforms ...
Xiaoyue Zhang   +17 more
wiley   +1 more source

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

open access: yesAdvanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo   +10 more
wiley   +1 more source

BInD: Bond and Interaction‐Generating Diffusion Model for Multi‐Objective Structure‐Based Drug Design

open access: yesAdvanced Science, EarlyView.
Can a generative model design molecules that truly understand their targets? BInD, a diffusion‐based framework, co‐generates 3D molecules and their interactions with proteins by learning target‐specific interacting patterns. With knowledge‐based guidance and NCI‐driven optimization, BInD balances affinity, geometry, and drug‐likeness – pushing the ...
Joongwon Lee   +3 more
wiley   +1 more source

Bio‐Inspired Strategy for Radiation‐Based Thermal Management and Utilization

open access: yesAdvanced Science, EarlyView.
Biological organisms have evolved remarkable strategies to manage and exploit thermal radiation. This review explores bio‐inspired systems that mimic these adaptations—such as radiative cooling, thermal regulation, thermal insulation, water harvesting, infrared camouflage, and infrared detection—and highlights their application in thermal management ...
Hyung Rae Kim   +5 more
wiley   +1 more source

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